维吾尔族老年单纯收缩期高血压患者超敏C反应蛋白与脉搏波速度及颈动脉内膜-中层厚度的相关性研究

Association among High-sensitivity C-reactive Protein, Pulse Wave Velocity and Carotid Intima-media Thickness in Uygur Elderly Patients with Isolated Systolic Hypertension

目的：探讨维吾尔族老年收缩期高血压（ ISH）患者超敏C反应蛋白（ hs-CRP）与颈-股动脉的脉搏波传导速度（ cfPWV）及颈动脉内膜-中层厚度（ IMT）的相关性。方法：选取维吾尔族老年ISH患者118例作为ISH组,维吾尔族老年原发性高血压（ EH）患者115例作为EH组,并选择年龄与之相匹配的维吾尔族血压正常人群（ NT）100例作为NT组。采用免疫透射比浊法测定血清hs-CRP水平；超声技术测定IMT,动脉硬化检测仪测定cfPWV。采用直线相关分析法分析hs-CRP与cfPWV及IMT的相关性。结果：ISH组、 EH组hs-CRP、 cfPWV及IMT均高于NT组（ P〈0．05）；ISH组hs-CRP、 cfPWV及 IMT 均高于 NT 组（ P 〈0．05）。相关性分析表明, hs -CRP 与 cfPWV、 IMT 呈正相关（ P 〈0．001）。结论：维吾尔族老ISH患者血清hs-CRP水平明显升高,且与cfPWV及IMT呈正相关。

OBJECTIVE： To investigate the association among high-sensitivity C-reactive protein （ hs-CRP） , carotid-fem-oral pulse wave conduction velocity （ cfPWV） and carotid intima-media thickness （ IMT） of Uygur elderly patients with isolated sys-tolic hypertension （ ISH） . METHODS： 118 Uygur old patients with isolated systolic hypertension （ ISH） were enrolled as ISH group. 115 patients with essential hypertension （ EH） were the EH group. Another 100 age-matched normotension （ NT） people were cho-sen as NT group. Serum hs-CRP was measured by turbidimetric immunoassay method. IMT was detected through ultrasound technol-ogy and cfPWV was measured by automatic arteriosclerosis detector. The association among hs-CRP, cf-PWV and IMT was de-scribed by linear correlation analysis. RESULTS： hs-CRP, cfPWV and IMT in ISH and EH groups were higher than those in NT group （P〈0. 05）, while the hs-CRP, cfPWV and IMT in ISH group were all higher than those in EH group （P〈0. 05）. The studies showed that hs-CRP was positively correlated with cfPWV and IMT （P〈0. 001）. CONCLUSION： hs-CRP level is signifi-cantly elevated in Uygur elderly patients with ISH and positively correlated with cfPWV and IMT.