114例小肝癌预后因素分析

An Analysis on Prognostic Factors for 114 Cases with Small Liver Cancer

[目的]分析小肝癌的临床、病理特点和预后因素。[方法]回顾性分析114例小肝癌患者的临床病理资料,对各临床病理因素与预后的关系进行分析。[结果]患者1、3、5年生存率分别为85.09%、69.30%、56.14%。单因素分析显示肿瘤大小、血清AFP水平等是预后影响因素,多因素分析则显示肿瘤大小、肝功能Child分级、肝硬化及门静脉癌栓是独立预后因素(RR=3.07,4.43,7.05,14.02,P均<0.01)。[结论]小肝癌具有与大肝癌相同的肝病史,门脉癌栓是最有价值的预后指标,早期发现及手术切除,能有效提高生存率。

[Purpose] To investigate the clinicopathologic features and prognostic factors of small liver cancer. [Methods] One hundred and fourteen cases with small liver cancer were enrolled. The relationship between various clinicopathologic factors and prognosis of the patients with small liver cancer was analyzed. [Results] The 1-,3- and 5-year survival rates of the patients were 85.09% ,69.30% and 56.14% respectively. Univariate analysis indicated that tumor size, AFP level were related to survival. Multivariate analysis demonstrated that tumor size,Child-Pugh score,hepatic cirrhosis and portal vein tumor thrombus were the independent prognostic factors （RR=3.07,4.43,7.05,14.02,P〈0.01）. [Conclusion] Small liver cancer has the same history of large liver cancer. Portal vein tu- mor thrombus is the most significant indicator for prognosis assessment. Early diagnosis and hepatic resection play an important role in improving survival.