我国结核病基础研究的回顾与展望

Review and prospect of basic research on tuberculosis in China

结核病基础科研围绕着人体与结核分枝杆菌斗争的方方面面全方位地展开,从结核分枝杆菌的基因组DNA到转录组RNA,从其表达的蛋白质到其代谢的产物,再到结核分枝杆菌对人体的致病作用及人体对其产生的免疫应答,希望寻找出干预的措施、控制的手段.研究内容非常丰富,篇幅所限,难以面面俱到,笔者只是根据中文文献试图阐述我国在细菌学、免疫学、分子生物学、疫苗、新药方面的主要研究和取得的重要进展,也试图指出研究的前景和存在的问题.

The basic research on tuberculosis carry out around all aspects of the struggle between the human body and M.tuberculosis,from the genomic DNA to the transcriptome RNA,from the protein expressed to the me tabolites,and then to the pathogenic role of M.tuberculosis on human body and the immune response produced by human body.Try to find out the intervention measures and control methods on tuberculosis.The research content is very rich.Owing to the limited space,this paper attempts to describe the main researches and their important pro gresses in bacteriology,immunology,molecular biology,vaccine,and new antbtuberculosis drug in China,and also tries to point out the research prospect and existing problems.