半边莲生物碱对肺动脉高压模型大鼠肺血管重构的影响

Effects of Lobelia Alkaloids on Pulmonary Vascular Remodeling of Pulmonary Arterial Hypertension Rat Models Induced by Monocrotaline

目的:观察半边莲生物碱对野百合碱(MCT)致肺动脉高压(PAH)模型大鼠肺血管及右心室重构的影响。方法:MCT一次性腹腔注射60 mg/kg体质量复制PAH模型大鼠,一周后给予半边莲生物碱灌胃,灌胃4周后,观察大鼠右心室肥厚指数(RVHI)、右心室质量指数(RVMI)以及肺小动脉形态学变化。结果:半边莲生物碱可显著降低PAH模型大鼠RVHI和RVMI以及肺小动脉管壁厚度,使管腔内径扩大。结论:半边莲生物碱早期干预后MCT致PAH模型大鼠肺小动脉和右心室的重构明显受到了抑制。

Objective ：To observe the effects of lobelia alkaloids on pulmonary vascular and right ventricular remodeling of pulmonary arterial hypertension（PAH） rat models induced by monocrotaline. Methods：The rats were given a dose of 60 mg/kg monocrotaline intraperitoneally to establish the PAH model,one week later, rats were given lobelia alkaloids by intragastric administration. After 4 weeks,we observed right ventricular hypertrophy index（RVHI）,right ventricular mass index（RVMI） and pulmonary morphological changes by HE staining. Results：Lobelia alkaloids could significantly reduce RVHI,RVMI,pulmonary artery wall thickness and expand inner diameter of pulmonary artery in PAH rats. Conclusion：Lobelia alkaloids can inhibit pulmonary artery and right ventricular remodeling of PAH rat model induced by MCT significantly.