放射性纤维化的临床干预现状及靶向治疗前景

Current Status of Clinical Intervention and Targeted Therapy for Radiation Fibrosis

放射性纤维化是放射性损伤的重要组成部分,而目前临床中仍缺乏有效方法预防治疗放射性纤维化。现有的干预放射性纤维化的方法包括抗炎治疗、高压氧疗、抗氧化治疗,已有临床资料证实其有效性,但仍需大型随机对照试验的进一步证实。随着人们对放射性纤维化病理过程的认识,许多潜在的治疗靶点被发现,包括TGFβ1、CTGF、酪氨酸激酶抑制剂。全文对放射性纤维化的临床现状及可选择的治疗靶点进行系统综述。

Radiation fibrosis is an important component of radiation injury,and the current clinical treatment still lacks effective methods to prevent radiation fibrosis. Clinical therapeutic interventions for radiation fibrosis includs：anti-inflammatory treatment,hyperbaric oxygen therapy and antioxidant treatment. Although some clinical trials have provided effective evidence for therapeutic efficacy,but it remains to be confirmed in large randomized controlled trials. As people＇s awareness of radiation fibrosis pathological process,many potential therapeutic targets are found,including：TGFβ1,CTGF,tyrosine kinase inhibitors. Clinical status and therapeutic target for radiation fibrosis are systematic reviewed in this paper.