摘要
A simple synthetic approach for the transformation of （S）-Ugi＇s amine, another configuration of （R）-Ugi＇s amine, one of the most widely used intermediate in the preparation of chiral ferrocene-based ligands, has been developed via esterification using anhydride, alkaline hydrolysis and active manganese dioxide oxidation, and the corresponding ferrocenyl ketone was afforded in good yields.
A simple synthetic approach for the transformation of （S）-Ugi＇s amine, another configuration of （R）-Ugi＇s amine, one of the most widely used intermediate in the preparation of chiral ferrocene-based ligands, has been developed via esterification using anhydride, alkaline hydrolysis and active manganese dioxide oxidation, and the corresponding ferrocenyl ketone was afforded in good yields.
基金
financial support from the National Natural Science Foundation of China (No.20972123)
Wuhan Science and Technology Bureau
