摘要
目的:观察氨甲环酸在脊柱结核手术围术期减少出血和输血、控制炎症反应的效果。方法:将60例行脊柱结核手术患者随机分为氨甲环酸组和空白对照组。氨甲环酸组于手术开始即刻给予氨甲环酸直至手术结束,空白对照组则给予等量生理盐水。观察患者术中出血和输血情况;分别于术前、手术结束即刻、术后6 h和术后24 h采集静脉血,检测白细胞介素-6(IL-6)和白细胞介素-10(IL-10)的水平。结果:患者术中出血和输血量两组存在显著差异,氨甲环酸组显著低于对照组;两组患者IL-6的血浆水平均高于术前,但氨甲环酸组显著低于对照组;IL-10的血浆水平术后氨甲环酸组显著高于空白对照组。结论:在脊柱结核手术中,氨甲环酸具有止血和抗炎的双重效果。
Objective： To evaluate the effects of tranexamic acid on hemostasis and inflammatory mediators in spinal tuberculosis surgery. Methods： 60 patients receiving spinal tuberculosis surgery were divided into two groups：tranexamic acid group（group TA） and control group（ group C）. Patients in group TA received tranexamic acid 50 mg · kg- 1 at the initiation of surgery followed by intravenous infusion of 10 mg ·（ kg · h）- 1 during surgery. Patients in group C received saline. Blood loss and allogeneic transfusion were observed. Interleukin-6（IL-6） and interleukin-10（IL-10） were tested at four time points：before the operation,at the end of the operation,6 h and 24 h postoperatively. Results： Blood loss and allogeneic transfusion were significantly lower in group TA than in group C. Serum concentration of IL-6 was higher postoperatively than preoperatively in group TA and in group C,but that in group TA was significantly lower than that in group C. Serum level of IL-10 was higher in group TA than that in group C. Conclusion： Tranexamic acid significantly reduces blood loss and allogeneic transfusion in patients having spinal tuberculosis surgery. It can also regulate inflmmation mediators.
出处
《现代医学》
2014年第8期847-849,共3页
Modern Medical Journal
基金
河北省科技支撑计划项目(11276140)
