医院感染嗜水气单胞菌的临床治疗分析

Clinical Treatment Analysis of Aeromonas Hydrophila for Hospital Infection

目的 探讨嗜水气单胞菌致医院感染的预防措施、治疗效果及耐药性.方法 收集2010年～2013年的15例感染嗜水气单胞菌的病人,其中5例痰标本,4例粪标本,6例分泌物标本.对感染的嗜水气单胞菌进行药敏分析并依据药敏进行治疗.结果 感染嗜水气单胞菌有5例肺炎型,4例急性肠胃炎型,6例皮肤感染型.且对青霉素和氨苄西林全部耐药,对多数第三、四代头孢类抗生素敏感率只有40％,对碳青霉烯类亚胺培南和美洛培南高度敏感,均为100％,对庆大霉素和左氧氟沙星敏感率为90％,氯霉素和四环素为70％.结论 嗜水气单胞菌引起非肠道感染增多,且耐药率较高,特别是免疫力低下及长期使用广谱抗生素的病人,病死率较高,应引起临床重视.

Objective To explore infection prevention measures,treatment effect and resistance of Aeromonas hydrophila for hospital infection.Methods Collected 15 patients infected with Aeromonashydrophila from 2010 to 2013,and there were 5 sputum specimens,4 fecal specimens and 6 secretion specimens among them Antimicrobial susceptibility test of Aeromonas hydrophila infected was done and made treatment based on Antimicrobial susceptibility test.Results Aeromonas hydrophila had five bacterium pneumonia,4 cases of acute gastrointestinal inflammatory and 6 cases of skin infection.All were resistant to penicillin and ampicillin,sensitive rate to most of the third or the fourth generation cephalosporin antibiotics was only 40 ％,of carbapenems imipenem and meropenem was 100 ％ （highly sensitive）,of gentamicin and levofloxacin was 90 ％,and of chloramphenicol and tetracycline was 70％.Conclusion Non intestinal infection caused by Aeromonas hydrophila was increased,and the resistant rate was higher,especially case fatality rate of the patients with low immunity or use of broad spectrum antibiotics in long term would be higher.It should be cause clinical attention.