纳米炭在乳腺癌腋窝前哨淋巴结活检中的临床应用

Application of carbon nanoparticle in the axillary sentinel lymph node biopsy for breast cancer

目的 探讨纳米炭对乳腺癌腋窝前哨淋巴结示踪的临床效果.方法 对57例乳腺癌患者,术前30 min于乳晕周围分4点及肿瘤表面皮肤皮下均匀注入纳米炭混悬注射液,找到腋窝黑染的第1枚淋巴结确定为前哨淋巴结,然后行改良乳腺癌根治术,观察纳米炭的应用价值.结果 成功检出前哨淋巴结56例,检出率为98.2％（56/57）,准确率为98.2％（55/56）,灵敏度为95.2％（20/21）,假阴性率为4.8％（1/21）,假阳性率为0.结论 纳米炭混悬注射液作为示踪剂能准确反映腋窝淋巴结转移状态,具有操作简便、定位准确、特异性强、染色时间长的优点,值得临床推广.

Objective To explore the clinical effect of carbon nanoparticle in the axillary sentinel lymph node tracer of breast cancer.Methods Fifty-seven patients with breast cancer underwent lymphatic tracing with carbon nanoparticle.The carbon nanoparticle suspension was subcutaneously injected around the areola （points at 4 o＇clock） and tumor surface skin at 30 min before operation.The first lymph nodes blacked were named sentinel lymph node.Then performed modified radical mastectomy,observing the application value of carbon nanoparticle.Results The detection rate of sentinel lymph node was 98.2％ （56/57）.The correct,sensitive and false negative rates were 98.2％（55/56）,95.2％（20/21） and 4.8％（1/21）,respectively.The false positive rate was 0.Conclusions The carbon nanoparticle suspension injection subcutaneously around areola in sentinel lymph node biopsy is helpful for accurately evaluating the axillary lymph node condition.Being simple to operate,accurate positioning,dyeing time and is worth popularizing.