声脉冲辐射力弹性成像技术评价乳腺癌新辅助化疗疗效的初步探讨

The preliminary research of the evaluation of ARFI technology in the efficacy of neoadjuvant chemotherapy for breast carcinoma

目的探讨声脉冲辐射力弹性成像(acoustic radiation force impulse imaging,ARFI)技术在乳腺癌新辅助化疗疗效评价中的应用价值。方法对2012年12月至2013年12月间我院经病理学证实的60例乳腺癌患者应用声脉冲辐射力成像技术,分别测量新辅助化疗前后肿瘤内部组织的横向剪切波速度(shear wave velocity,SWV),分析其化疗前后的变化,并与病理结果结合对照研究。结果新辅助化疗前后肿瘤组织的SWV变化差异有统计学意义,应用ARFI技术评价乳腺癌新辅助化疗疗效,ARFI技术评价的特异度、灵敏度分别为85.7%、89.1%,ARFI技术评价的总有效率为71.7%,ARFI技术评价与病理学评价比较,两者差异无统计学意义。结论 ARFI技术为乳腺癌新辅助化疗的疗效评价提供了定量的影像学评价方法,能对乳腺癌新辅助化疗的疗效做出客观评价,具有一定的临床应用价值。

Objective To explore the application values of ARFI （acoustic radiation force impulse imaging） technology in evaluating effect of neoadjuvant chemotherapy for breast carcinoma. Methods 60 patients who went to our hospital for physical examinations during 2012 December to 2013 December were enrolled in the research. And every lesion was measured the transverse shear wave velocity of the interior tumor around the neoadjuvant chemotherapy（NAC） ,and compared with the pathological results. Results There were significant differences in SWV changes in tumor tissue before and after NAC. The NAC of ARFI technology in evaluating breast cancer specific ARFI technology evaluation, the sensitivity and respectively of the application values of ARFI technology in evaluating effect of NAC for breast carcinoma were 85.7 % and 89.1% ,and the total efficiency was 71.7 %. Compared with the pathological evaluation, there was no statistically significant in the differences. Conclusion The ARFI technology provide quantitative elasticity measurements to make objective evaluation for the effect of NAC which has certain clinical application value.