磷酸肌酸钠治疗小儿病毒性心肌炎疗效的Meta分析

Therapeutic Efficacy of Creatine Phosphate Sodium for Viral Myocarditis in Children:A Meta-analysis

目的:系统评价磷酸肌酸钠(CPS)对小儿病毒性心肌炎(VMCC)的疗效,以为临床提供循证参考。方法:计算机检索Cochrane Library、PubMed、Medline、EMBase、中国学术期刊网络出版总库、万方数据库、维普数据库、中国生物医学文献数据库、中国博士学位论文全文数据库和中国优秀硕士学位论文全文数据库,收集有关CPS治疗VMCC的随机对照试验(RCT),提取资料并进行质量评价后,采用Rev Man 5.2.3统计软件进行Meta分析。结果:共纳入13项RCT,合计1 195例患者。Meta分析结果显示,试验组患者总有效率[OR=5.16,95%CI(3.48,7.65),P<0.000]、心肌酶谱转阴率[OR=2.86,95%CI(1.97,4.14),P<0.000]、心电图转阴率[OR=2.32,95%CI(1.46,3.70),P<0.000]显著高于对照组,两组比较差异有统计学意义。结论:CPS治疗VMCC疗效较好。由于纳入研究数量较少、质量不高,该结论还需要大样本、高质量的RCT进一步验证。

OBJECTIVE：To evaluate the therapeutic efficacy of creatine phosphate sodium（CPS）on pediatric viral myocarditis（VMCC）,and to provide evidence-based reference for the clinic. METHODS：Retrieved from Cochrane Library,PubMed,Medline,EMBase,CNKI,Wanfang database,VIP,CBM,CDFD,CMFD,RCT about CPS in the treatment VMCC were collected and evaluated in quality. Meta-analysis was performed by using Rev Man 5.2.3 software. RESULTS：A total of 13 RCTs were included,involving 1 195 patients. Meta-analysis showed that the total efficiency [OR=5.16,95%CI（3.48,7.65）,P〈0.000],negative rate of cardiac enzymes [OR=2.86,95% CI（1.97,4.14）,P〈0.000] and negative rate of ECG [OR=2.32,95% CI（1.46,3.70）,P〈0.000] in trial groups were significantly higher than in control group;there were statistical significance. CONCLUSIONS：VMCC is effective for CPS. Due to the small scale and low quality of included stuies,the conclusion should be confirmed by more large-scale and high-quality RCTs.