个体化用药教育对冠心病患者临床疗效的影响

Effects of Individualized Medication Education on Clinical Efficacy in Patients with Coronary Heart Disease

目的:探讨个体化用药教育对冠心病患者临床疗效的影响。方法:将168例冠心病患者随机均分为对照组和干预组,对照组予以常规治疗(所用药物包括美托洛尔、硝酸甘油、辛伐他汀等),干预组在此基础上从药物种类、作用特点、剂量调整、不良反应及处理等方面对患者进行用药教育。两组患者均治疗8周后进行评价。调查两组患者对用药知识的掌握情况,比较用药依从性、临床疗效、不良反应等方面的差异。结果:干预组患者干预后用药知识得分显著高于对照组(P<0.01);干预组患者的总依从率、心绞痛症状和心电图改善的总有效率均显著高于对照组,不良反应总发生率显著低于对照组,差异均有统计学意义(P<0.01)。结论:个体化用药教育能显著提高冠心病患者对药物的认知,增加用药依从性和临床疗效,降低不良反应发生率。

OBJECTIVE：To study the effects of individualized medication education on clinical efficacy in patients with coronary heart disease. METHODS：168 patients with coronary heart disease were randomly divided into control group and intervention group. Control group was given routine chemotherapy（including metoprolol,glyceryl trinitrate,simvastatin）;intervention group was additionally given medication education in terms of the types of drugs,role and characteristics,dosage adjustment,ADR and disposal,etc. on the basis of control group. Clinical efficacies of 2 groups were evaluated after 8 weeks of treatment. The drugs-related knowledge of patients was investigated,and the difference of drug compliance,clinical efficacy and ADR were compared between 2 groups. RESULTS：After intervention,intervention group was superior to control group in drugs-related knowledge（P〈0.01）. Total rate of drug compliance,total effective of angina pectoris and ECG improvement were significantly higher in intervention group than control group. The incidence of ADR in intervention group was lower than in control group;there was statistical significance（P〈0.01）. CONCLUSIONS：Individualized medication education can significantly improve the drugs-related knowledge of patients with coronary heart disease,promote medication compliance and clinical efficacy and reduce the incidence of ADR.