心脉隆注射液对老年慢性心力衰竭患者脑钠肽前体及肌钙蛋白Ⅰ的影响

Effects of Xinmailong Injection on Pro- Brain Natriuretic Peptide and TroponinⅠ in Elderly Patients with Chronic Heart Failure

目的探讨心脉隆注射液对老年慢性心力衰竭(CHF)患者脑钠肽前体(proBNP)及肌钙蛋白I(CTnⅠ)的影响。方法收集医院70岁以上CHF住院患者92例,随机分为两组。对照组43例予CHF常规治疗;心脉隆组49例在CHF常规治疗基础上加用心脉隆注射液300 mg/d静脉滴注治疗14 d。治疗前后分别检测患者proBNP及CTnⅠ水平、6 min步行试验(6MWT)距离。结果 92例患者中,随着NYHA心功能分级增加,患者proBNP及CTnⅠ水平均上升,而6MWT距离下降;治疗14 d后,两组患者proBNP及CTnⅠ水平均较治疗前降低,6MWT距离较治疗前增加;治疗后心脉隆组患者较对照组患者proBNP更低[(410.97±74.56)pg/mL比(476.75±80.21)pg/mL,P=0.000],CTnⅠ亦更低[(0.06±0.03)ng/mL比(0.08±0.04)ng/mL,P=0.008],而6MWT距离[(431.78±42.58)m比(406.25±46.31)m,P=0.007]较对照组增高。结论心脉隆注射液能改善老年CHF患者的心功能。

Objective To investigate the effects of Xinmailong Injection on pro-brain natriuretic peptide （ proBNP ） and troponin Ⅰ（ CTnⅠ） in elderly patients with chronic heart failure （ CHF ） Methods 92 inpatients aged over 70 years with CHF were collected and randomly divided into the two groups. The control group （ 43 cases ） was given the CHF conventional treatment, while on this basis the Xinmailong group （ 49 cases ） was added with Xinmailong Injection 300 mg/d by intravenous drip for 14 d. The levels of proBNP and CtnI were detected and the 6-min walk test （ 6MWT ） was performed before and after treatment. Results Among 92 cases, with the NYHA cardiac functional grading increase, the levels of CTnI and proBNP were elevated, while the distance of 6MWT was decreased;af-ter 14 d treatment, the CTnI and proBNP levels of the two groups were decreased, while the distance of 6MWT was raised compared with before treatment; the proBNP and CTnI levels after treatment in the Xinmailong group lower than those in the control group [ （ 410. 97 ± 74. 56 ） pg/mL vs. （ 476. 75 ± 80. 21 ） pg/mL, P=0. 000; （ 0. 06 ± 0. 03 ） ng/mL vs. （ 0. 08 ± 0. 04 ） ng/mL, P=0. 008 ];the dis-tance of 6MWT in the Xinmailong group was increased compared with the control group [ （ 431. 78 ± 42. 58 ） m vs. （ 406. 25 ± 46. 31 ） m, P=0. 007 ） . Conclusion Xinmailong Injection can improve the heart function in elderly patients with CHF.