中西医结合治疗早期糖尿病肾病50例临床观察

Clinical observation of 50 cases of patients with early diabetic nephropathy treated by combined therapy of Chinese and Western medicine

目的观察中西医结合治疗早期糖尿病肾病(DN)的临床疗效。方法将100例DN患者随机分为2组。治疗组50例予中药灌肠联合银杏达莫注射液治疗,对照组50例予西医常规治疗。2组均治疗1个月后统计疗效、中医证候评分和实验室指标变化情况。结果治疗组总有效率高于对照组(P<0.05),治疗组疗效优于对照组。治疗组治疗后主要中医证候评分均较本组治疗前下降(P<0.05),而对照组治疗后只有口渴喜饮、气短懒言2个中医证候评分较治疗前下降(P<0.05);治疗组治疗后主要中医证候评分均低于对照组治疗后(P<0.01)。2组治疗后空腹血糖(FPG)、尿微量白蛋白(mAlb)、血及尿β2微球蛋白(β2-MG)均较本组治疗前均降低(P<0.05);治疗组治疗后FPG、mAlb、血β2-MG及尿β2-MG均较对照组治疗后降低(P<0.05)。2组治疗后血清总胆固醇(TC)、甘油三酯(TG)均较本组治疗前降低(P<0.01);治疗组治疗后TC、TG均较对照组治疗后降低(P<0.01)。结论中西医结合治疗早期DN能明显提高疗效,改善患者中医证候评分,减轻或消除患者的临床症状,改善肾功能。

Objective To observe the effect of patients with early diabetic nephropathy treated by combined therapy of Chinese and Western medicine. Methods 100 cases of DN were randomly divided into two groups. 50 cases in treatment group were treated by Chinese medicine enema combined with Yinxingdamo injection. 50 cases in control group were given western medicine conventional treatment. The efficacy and TCM syndrome score and lab in- dex changes were observed after a month of treatment. Results The total effective rate in treatment group was higher than that in control group （ P 〈 0.05 ）. The main TCM syndrome score after treatment was decreased as compared with that before treatment in treatment group （ P 〈 0.05 ）. Two TCM syndrome score of thirsty like drinking, shortness of breath lazy after treatment was decreased as compared with that before treatment in control group （ P 〈 0.05 ）. The main TCM syndrome score in treatment group was lower than that in control group after treatment （P 〈 0.01 ）. FPG, mALBTC and β2 - MG in serum and urine after treatment were decreased as compared with those before treatment in two groups （ P 〈 0.05 ）. FPG, mALBTC and β2 - MG in serum and urine in treatment group were decreased as compared with those in control group after treatment （ P 〈 0.05）. TC and TG after treatment were decreased as compared with those before treatment in two groups （ P 〈 0.05 ）. TC and TG in treatment group were lower than those in control group after treatment （ P 〈 0.05 ）. Conclusion The combined therapy of Chinese and Western medicine on patients with early diabetic nephropathy can significantly improve the efficacy, improve patient TCM syndrome score, reduce or eliminate the clinical symptoms and improve kidney function