溃疡性结肠炎患者QT离散度与疾病临床特征的相关性分析

目的：通过监测溃疡性结肠炎患者（UC）常规心电图，探讨UC患者长QT离散度与疾病临床特征的相关性。方法共纳入经临床、内镜及病理确诊的UC患者55例，并以50例健康体检者为对照组。分别检测两组的心电图和血清生化功能指标，并计算校正QT离散度（QTcd）和稳态模型评估的胰岛素抵抗指数（HOMA-IR）。结果与对照组相比，10.9%的UC患者存在长QTcd（P〈0.05），且UC患者的平均年龄更大（P〈0.05）。相比正常QTcd患者，长QTcd患者的血清胰岛素水平更高（7.00±1.46）vs（9.45±1.51）（P〈0.05），HOMA-IR值亦更高（2.21±0.64）vs（3.66±0.60）（P〈0.05）。同时吸烟与QTcd延长存在相关性。结论溃疡性结肠炎患者或更易发生长QTcd，对于这部分患者应常规进行心电图检查。

ObjectiveTo investigate the relationship between prolonged QT dispersion and ulcerative colitis（UC）by analyzing the electrocardiography of ulcerative colitis patients.Method The study included 55 UC patients and 50 healthy people as the control group. Both groups underwent electrocardiography and serum biochemical parameters tests. Corrected QT dispersion （QTcd）was calculated using Bazett’s formula and homeostasis model assessment（HOMA）was used to determine insulin resistance（IR）.Result Compared with the control group, prolonged QTcd was found in 10.9% of UC patients, and average age of UC patients was older than that of the control group（P〈0.05）. A significant difference was found between the insulin values （7.00±1.46 vs 9.45±1.51,P〈0.05）and HOMA-IR（2.21±0.64 vs 3.66±0.60,P〈0.05）in UC patients with and without prolonged QTcd. Smoking was significantly associated with prolonged QTcd.ConclusionUC patients may be apt to develop prolonged QTcd and these patients should routinely take electrocardiography.