VEGF在子宫颈癌及上皮内瘤变组织的表达及意义

目的：探讨血管内皮生长因子（vascular endothelial growth factor，VEGF）在子宫颈癌及宫颈上皮内瘤变的表达及意义。方法采用免疫组织化学S-P法检测95例子宫颈癌（ICC）、67例宫颈上皮内瘤变（CIN）和104例正常宫颈上皮（NCE）中VEGF的表达情况，同时检测微血管密度（MVD，CD34标记）和癌细胞增殖标记指数（Ki-67标记），将后两者与VEGF表达进行比较。结果正常宫颈上皮VEGF不表达或弱表达，上皮内瘤变和子宫颈癌VEGF阳性表达，并且表达率显著升高（P〈0.05），与组织学分级、癌细胞增殖指数（Ki-67）、MVD显著正相关（r=0.602，P〈0.01），但与年龄、FIGO分期和间质浸润无关（P〉0.05）。结论 VEGF与子宫颈癌变的发生、发展关系密切，可以作为监测宫颈癌及判断预后的参考指标。

ObjectiveTo study the vascular endothelial growth factor（vascular endothelial growth factor,VEGF）in cervical cancer and the expression and significance of cervical intraepithelial neoplasia .MethodsUsing immunohistochemical S-P method to detect 95 example cervical cancer（ICC）,67 cases of cervical intraepithelial neoplasia（CIN）and 104 cases of normal cervical epithelium（an NCE）the expression of VEGF in the situation,at the same time to detect microvascular density（MVD,CD34 markers）and cancer cell proliferation index of tag（Ki-67）,which will both be compared with VEGF expression.ResultsVEGF is not expressed or weekly expressed in normal cervical epithelium while is of positively expression in intraepithelial neoplasia and cervical cancer,and the expression rate increased significantly（P〈0.05）,which is also positively correlated with the the histologic grading,cancer cell proliferation index（Ki-67）and the MVD（r=0.602,P〈0.01）,but is not related to age,FIGO staging,and interstitial infiltration（P〉0.05）.ConclusionVEGF is close to the occurrence and development of cervical cancer,and can be used as a reference index to monitoring of cervical cancer and prognosis.