莫西沙星治疗急性盆腔炎临床效果观察

Clinical Effect of Moxifloxacin Treatment Acute Pelvic Inflammatory Disease

目的观察莫西沙星治疗急性盆腔炎临床效果,探讨其应用价值。方法选择2007年1月至2012年1月急性盆腔炎患者92例作为研究对象,随机分成观察组及对照组各46例,观察组给予莫西沙星400mg/d,先静脉给药3d,待病情好转(改善)或体温正常后8h,改为口服,剂量不变,疗程14d;对照组左氧氟沙星300mg+甲硝唑500mg,静滴,每日1次,共14d。结果观察组总有效率95.65%高于对照组的76.05%;临床症状改善时间(3.05±1.67)d、静脉给药时间(6.78±1.23)d、住院时间(9.12±1.56)d均短于对照组的(4.82±2.01)d、(14.00±0.00)d、(17.98±2.67)d(P<0.05)。观察组药物不良反应6.52%低于对照组的23.91%。结论莫西沙星单药治疗与左氧氟沙星加甲硝唑联合治疗方案相比,临床疗效高,发生不良反应低,值得临床应用。

Objective To observe the clinical effect of moxifloxacin treatment of acute pelvic inflammatory disease,to explore the application value. Methods Select January 2007 to January 2012 acute pelvic inflammatory disease 92 patients as the research object,randomly divided into observation group and control group each 46 case,the observation group were given moxifloxacin 400mg/d,first intravenous administration of 3d,to be better（improve） or normal body temperature after 8h,changed to oral,constant dose,duration 14d,the control groupLevofloxacin 300mg＋ metronidazole 500mg,intravenous drip,1 times daily,14D. Results Total effective rate of observation group 95. 65% is higher than the control group 76. 05%;the clinical symptoms improved time（3. 05 ± 1. 67）d,intravenous administration time（6. 78 ± 1. 23）d,hospitalization time（9. 12 ± 1. 56 d are shorter than the control group（4. 82 ±2. 01）d,（14. 00 ±0. 00）d,（17. 98 ±2. 67）d（P〈0. 05）. Observation group adverse reaction of drugs 6. 52% lower than that of the control group 23. 91%. Conclusion Moxifloxacin monotherapy compared with the combination therapy of moxifloxacin monotherapy and left of loxacin Clinical efficacy, adverse reactions,it is worthy of clinical application.