小剂量米力农在治疗老年性顽固性心力衰竭患者的临床观察

The Analysis Efficacy and Safety of Taking Small Dose Milrinone in theTreatment of Elderly Patients with Intractable Heart Failure

目的观察小剂量米力农治疗老年患者顽固性心力衰竭的疗效及安全性。方法将老年顽固性心力衰竭住院患者分为两组,对照组为常规剂量使用米力农,观察组为小剂量使用米力农,分别在治疗前后5d记录心功能、NTproBNP、LVEF、心律、血压的情况。结果两组心功能、NT-proBNP均较用药前有明显改善,有效率分别为93.1%、92%,两组的有效率无差异(P>0.05),EF变化不大;而观察组心律失常及低血压的发生率低于对照组。结论小剂量米力农治疗老年顽固性心力衰竭有效、安全。

Objective To evaluate the efficacy and safety of using small dose milrinone in the treatment of elderly patients with intractable heart failure. Methods The elderly patients with intractable heart failure were divided into two groups. The control group were taken conventional dose milrinone, and the observation group were taken small dose milrinone. The data of heart function, NT-proBNP, LVEF, heart rate, blood pressure were recorded before and after the treatment for 5 days. Results The heart function, pro-BNP of two groups were significantly improved compared with those before treatment, and the effective rate of control group and observation group were 93. 1% and 92% respectively, but the effective rate were not significantly different（ P 〉0. 05）. EF were not significantly improved. The occurrence rate of arrhythmias and hypotension in the observation group were lower than the control group. Conclusion small dose milrinone should be more effective and safe in the treatment of elderly patients with intractable heart failure.