三种血清学肿瘤标志物与食管癌分期的价值

The Value of Serum CYFRA21-1,CA125 and CA72-4 in Clinical Staging Esophageal Cancer

目的探讨了血清CYFRA21-1、CA72-4、CA125同食管癌患者病理分期的相关性。方法采用放射免疫分析法检测79例正常健康对照者、190例食管癌患者血清CA125、CA72-4和CYFRA21-1的浓度水平,同时采集患者病理分期资料并进行分析。结果从数值来看CYFRA21-1、CA125、CA72-4随分期的增加其水平呈增高趋势。CYFRA21-1组中Ⅱa期(P<0.01)、Ⅲ期(P<0.05)、Ⅳ期(P<0.01)及淋巴结阳性组(P<0.01)同正常对照组比较有统计学意义;Ⅱb、Ⅲ期、Ⅳ期同0期比较有统计学意义(P<0.01);Ⅳ期同Ⅰ期比较有统计学意义(P<0.05);CA125Ⅳ期同0期比较有统计学意义(P<0.01);CA72-4各组间均无统计学意义,三指标水平淋巴结阳性组同正常对照组比较有统计学意义(P<0.01)。CA125与不同pT分期具有明显相关性(r=0.210,P<0.05),余指标与分期均无相关性。结论 CYFRA21-1可以区分食管癌早期(0期和/或Ⅰ期)与晚期(Ⅱb期,Ⅲ期,Ⅳ期),CA125可以区分食管癌0期与Ⅳ期;CA125与pT分期明显相关性。

Objective To investigate the clinical value of the serum levels of CA125, CA72-4 and CYFRA21-1 in staging of esophageal cancer patients. Methods The serum levels of CA125 ,CA72-4 and CYFRA21-1 in 190 esophageal cancer patients and 79 healthy controls were measured by radioimmunoassay. The clinical pathological parameters in esophageal cancer patients were collected and analyzed. Results The serum levels of CYFRA21-1, CA72-4 and CA125 in esophageal cancer patients were increasing as their staging increased. The CYFRA21-1 levels in patients in stage of Ⅱ a, Ⅲ, Ⅳ, and the lymph node positive group had statistical difference with the healthy control group （P 〈0.05 ）. The CA125 levels in patients between stages of Ⅳ and Ⅰ had statistical difference （ P 〈 0. 05 ）. The CA72-4 levels in patients in all stages had no statistical significant. Conclusion The serum CYFRA21-1 could be used to identify the early stage （stage 0 and Ⅰ ）and advanced stage （stage Ⅱ b, Ⅲ and Ⅳ ）. The serum CA125 might be used toidentify the early stage and advanced stage, and the serum CA125 is obviously correlated with pT staging in esophageal cancer patients.