核素功能显像及MRI形态检查对眼脉络膜黑色素瘤的影像诊断价值

Diagnostic Value of Radionuclide Functional Imaging and MRI Morphological Imaging on Ocular Choroidal Melanoma

目的通过观察眼脉络膜黑色素瘤的核素功能性显像及MRI形态学成像表现,探讨二者对脉络膜黑色素瘤的诊断价值。方法回顾性分析28例(28只眼)经眼超声和(或)彩色超声多普勒血流成像、CT、眼底血管造影及临床评价等综合诊断为脉络膜黑色素瘤患者资料(男11例,女17例,平均年龄为44.3±13.8岁),所有患者均行过核素功能性显像及MRI形态学检查。结果核素功能性显像示病变部位最大计数/枕骨平均计数(Tmax/Oavg)与对侧最大计数/枕骨平均计数(Nmax/Oavg)之间差异有统计学意义(t=4.134,P<0.01),病变部位平均计数/枕骨平均计数(Tavg/Oavg)与对侧平均计数/枕骨平均计数(Navg/Oavg)之间差异同样有统计学意义(t=4.620,P<0.01)。有78.57%(22/28)患者存在整合素高表达。MRI显示支持诊断20例。结论核素功能性显像及MRI形态学检查联合应用是目前对于此类疾病最佳的诊断方法。

Objective To investigate the diagnostic value of radionuclide functional imaging and MRI morphological imaging on choroidal melanoma. Methods A retrospective analysis of 28 patients （ 11 men, 17 women; mean age ＋ SD,44.3 ± 13.8 y） with choroidal melanoma diagnosed by the comprehensive imaging diagnosis, including ocular ultrasound and （or） by color Doppler flow imaging, CT, fluorescein angiography were carried out. All patients underwent radionuclide functional imaging and MRI morphological imaging. Results Radionuclide functional imaging showed that there was significant difference between the ratio of Tmax/Oavg and Nmax/Oavg（t = 4. 134, P 〈 0.01 ）, there was also significant difference between Tavg/Oavg and Navg/Oavg （ t = 4. 620, P 〈 0.01 ）. There were 78.57 % （22/28） in patients with high expression of integrin αvβ3 which MRI diagnosed in 20 patients. Conclusion Combined application of radionuclide functional imaging and MRI morphological imaging might be prefer methods of diagnosis in this group of patients with choroidal melanoma.