泸州地区女性人乳头状瘤病毒感染与宫颈病变关系研究

Study of the relation between HPV infection and cervix lesion in Luzhou region

目的:应用膜杂交多重检测技术进行人乳头状瘤病毒(HPV)基因分型诊断,结合宫颈活体组织检查探讨泸州地区女性HPV感染与宫颈病变的关系。方法:采用膜杂交多重检测技术对泸州地区1142例门诊就医和体检女性进行HPV感染定性检测和型别诊断,结果为阳性者建议做宫颈活体组织检查。结果:在1142例标本中,共检出HPV阳性标本301例,阳性率为26.36%,共检出18种基因型,高危型以HPV16、58感染为主,低危型以HPV6、11感染为主。接受宫颈活体组织检查的225例HPV阳性女性中,检出宫颈上皮内瘤变及浸润癌共112例(CINⅠ28例,CINⅡ25例,CINⅢ46例,浸润癌13例)。结论:HPV分型检测联合组织学检查能及时有效地筛查宫颈疾病,为宫颈癌的防治提供可靠的科学依据。

Objective： To study the relation of HPV infection to cervix lesion in Luzhou area. Methods：Multiplex membrane hybridization technique was used to detect HPV infectious types among 1142 women and the HPV positive ones colposcopic biopsy was recommended. Results： Among 1142 women, 301 were found with positive HPV, the positive rate was 26.36%, a total of 18 genotypes were screened out. HPV16 and 58 were the main high risk HPV genotypes, and HPV6 and 11 were the main low risk HPV genotypes. 225 cases of HPV positive women received cervical biopsy, cervical intraepithelial neoplasia（CIN） and invasive carcinoma were detected in 112 cases（CINⅠ28 cases,CINⅡ25 cases andCINⅢ 46 cases and invasive carcinoma 13 cases）.Conclusion： HPV typing determination combined biopsy can screen out cervix lesion effectively for timely prevention and treatment.