COPD急性加重期纤维蛋白原和D-二聚体水平与预后的关系研究

Correlation between Levels of Fibrinogen and D- dimer and Prognosis of Patients with Acute Exacerbation of COPD

目的探讨COPD急性加重期(AECOPD)患者纤维蛋白原(FIB)和D-二聚体水平与预后的关系。方法选择2012年8月—2013年8月江苏盛泽医院收治的AECOPD患者134例为研究对象,依据患者预后分为无呼吸衰竭组(WRF组,39例)、呼吸衰竭好转组(RFI组,48例)、呼吸衰竭死亡组(RFD组,47例)。对比分析3组患者的FIB、D-二聚体水平以及二者与AECOPD患者预后的关系。结果 RFD组与RFI组FIB、D-二聚体水平高于WRF组,RFD组高于RFI组(P<0.05)。Spearman相关分析显示,FIB、D-二聚体水平均与AECOPD患者的预后呈正相关(r=0.764,P=0.002;r=0.832,P=0.000)。结论 AECOPD患者FIB、D-二聚体水平升高,且与AECOPD患者预后呈正相关,在临床治疗时应予以监测。

Objective To study the correlation between levels of fibrinogen（ FIB）and D-dimer and prognosis of pa-tients with acute exacerbation of COPD （ AECOPD ） . Methods A total of 134 patients with AECOPD who were treated in Shengze Hospital of Jiangsu Province from August 2012 to August 2013,were selected as study subjects,the patients were divid-ed into three groups：without respiratory failure group（ WRF group,39 cases）,respiratory failure improvement group（ RFI group,48 cases）,and respiratory failure death group（RFD group,47 cases）. The FIB and D-dimer levels were compared a-mong three groups of patients,as well as the correlation between levels of FIB and D -dimer and prognosis of AECOPD pa-tients. Results Levels of FIB and D-dimer in RFD group and RFI group were significantly higher than those in WRF group, while levels of FIB and D-dimer in RFD group were significantly higher than those in RFI group,the differences were statistical-ly significant（P〈0. 05）. According to the Spearman correlation analysis results,levels of FIB and D-dimer were positively correlated with prognosis of AECOPD patients（r=0. 764,P=0. 002;r=0. 832,P=0. 000）. Conclusion FIB and D-di-mer levels in patients with AECOPD are high,and are positively correlated with prognosis of AECOPD patients,FIB and D-di-mer should be monitored during clinical treatment.