背部腧穴药物注射治疗慢性阻塞性肺疾病急性加重期患者的临床疗效研究

Clinical Effect of Back Acupoint Injection on Acute Exacerbation of Chronic Obstructive Pulmonary Disease

目的探讨背部腧穴药物注射治疗慢性阻塞性肺疾病急性加重期患者的临床疗效。方法选取我院2008—2012年收治的慢性阻塞性肺疾病急性加重期患者360例,随机分为A、B、C 3组,每组120例。3组患者入院后均进行常规治疗,A组患者给予决明茶碱、薯芋皂甙、莨菪碱溶液2 ml背部腧穴注射,B组患者给予决明茶碱、薯芋皂甙、莨菪碱溶液2 ml肌肉注射,C组患者给予二丙茶碱0.5 g＋甲泼尼龙40 mg＋0.9%氯化钠溶液250 ml静脉滴注。观察3组患者起效时间、临床疗效、治疗前及治疗30 min后肺功能。结果 A组患者起效时间为5-15 min,B组为30-45 min,C组为20-30 min。A组患者总有效率为97.5%,B组为56.7%,C组为93.3%,A、C组患者总有效率均高于B组（P〈0.05）,而A组与C组总有效率比较,差异无统计学意义（P〉0.05）。3组患者治疗前用力肺活量（FVC）、用力呼气量（FEV）及最大呼气中期流量（MMEF）比较,差异均无统计学意义（P〉0.05）;治疗后,A组患者FVC、FEV、MMEF大于B组（P〈0.05）,而A组与C组、B组与C组FVC、FEV、MMEF比较,差异均无统计学意义（P〉0.05）。结论背部腧穴药物注射治疗慢性阻塞性肺疾病急性加重期患者起效快,作用迅速,可有效改善其肺功能,缓解其临床症状,临床疗效较好,安全性较高。

Objective To investigate the clinical effect of back acupoint injection on acute exacerbation of chronic obstructive pulmonary disease. Methods From 2008 to 2012,a total of 360 patients with acute exacerbation of chronic obstructive pulmonary disease were selected,and then they were randomly divided into groups A,B,C,120 cases in each. All patients given routine treatment after admission,and then A group given back acupoint injection（2 ml solution of cassia tora theophylline＋ potato taro saponins ＋ hyoscyamine）,B group given muscle injection（2 ml solution of cassia tora theophylline ＋ potato taro saponins ＋ hyoscyamine）,C group given intravenous drip（dipropyl theophylline 0. 5 g ＋ methylprednisolone 40 mg ＋ 0. 9% sodium chloride solution 250 ml）. Onset time,clinical effect,lung function before treatment and 30 minutes after treatment of the three groups were observed. Results The onset time of A group was 5 to 15 minutes,that of B group was 30 to 45 minutes,that of C group was 20 to 30 minutes. The total effective rate of A group was 97. 5%,that of B group was 56. 7%,that of C group was 93. 3%,the total effective rate of A group and C group was higher than that of B group（P〈0. 05）,while there was no significant difference between groups A and C（ P〈0. 05）. There was no significant difference of FVC,FEV and MMEF in the three groups before treatment; after treatment,FVC,FEV and MMEF of A group were higher than those of B group（ P〉0. 05）,while those between groups A and C,groups B and C was not statistically different（ P〈0. 05）. Conclusion Back acupoint injection has certain effect on acute exacerbation of chronic obstructive pulmonary disease,its onset time is short,can effectively improve the lung function,relief the clinical symptoms,and is safe.