益生菌预防抗生素相关性菌群失调的临床研究

Clinical study on probiotics in preventing antibiotic- associated dysbacteriosis

目的:探讨以双歧杆菌为主的益生菌预防抗生素相关性肠道菌群失调的作用。方法:将200例需要长时间应用抗生素的患者随机分为治疗组和对照组,治疗组在使用抗生素治疗的同时加用双歧杆菌三联活菌胶囊(培菲康)630 mg,每天3次,口服,分别观察两组患者肠道菌群失调发生率。结果:肠道菌群失调发生率治疗组为9%,对照组为37%,两组比较差异有统计学意义(P<0.01),肠道菌群失调发生与基础疾病和年龄有相关性。结论:益生菌可以有效预防抗生素相关性肠道菌群失调的发生,使用抗生素患者应该同时服用益生菌药物。

Objective： To investigate the effect of probiotics mainly with bifidobacterium in the prevention of antibiotic - associated intestinal dysbacteriosis. Methods：Tow hundreds patients who needed a long time use of antibiotics were randomly divided into treatment group and control group. The treatment group was treated with oral bifidobacterim capsules ,2 capsules, 3 times daily. The incidence of intestinal dysbacteriosis was observed in the two groups of patients. Results ：The incidence of intestinal dysbacteriosis in treatment group and control group patients was 9% and 37%. The difference between the two groups was statistically significant（ P 〈 0. 01 ）. The incidence of intestinal dysbacteriosis was related to the primary diseases and age. Conclusion ： Probiotics can be effective in preventing incidence of antibiotic - associated intestinal dysbacteriosis. The use of antibiotics in patients should also take probiotics drug at the same time.