结直肠癌老年患者FOLFOX4全身化疗不同输液方式不良反应临床观察

The side effects observation of different infusion methods for elderly patients with rectual cancer or conlon cancer were treated by FOLFOX4

目的：针对结直肠癌老年患者采用FOLFOX4方案全身化疗,探讨外周中心静脉置管术（PICC）较以往输液方式有无优势。方法：将163例老年结直肠癌患者随机分为PICC组、经锁骨下中心静脉置管术（CVC）组、浅静脉留置针组,采用FOLFOX4全身化疗2~4周期,观察静脉炎、药物外渗、导管堵塞发生率以及问卷调查输液方式对生活质量的影响。结果：与其他组比较,PICC组可明显减低静脉炎、药品外渗发生率,差异有统计学意义（P〈0.05）。问卷调查显示,所有患者可接受此种输液方式。结论：PICC在老年结直肠患者FOLFOX4化疗中,安全性高,能为患者所接受。

Objective：When the elderly patients with rectual cancer or conlon cancer were treated by FOLFOX4 chemo- therapy, to explore whether peripherally Inserted Central Catheters （PICC） is better than past infusion methods. Methods： All 163 patients cured by FOLFOX4 were divided into 3 groups with different infusion methods： PICC group,central venous catheterization（CVC） group, superficial vein detaining needle group. To observe the incidence of phlebitis, drug extravasation and pipes blockage after cured by FOLFOX4 for 2 - 4 weeks. Questionnaire survey to all patients whether quality of life was infunced by the infusion method. Results ：To compare other groups, the rates of phlebitis and drug extravasation were descented significantly（P 〈0.05）. All patients could accept the infusion method. Conclution：PICC was safer and accepted by patiants, could he extended in clinic.