中西医结合疗法治疗肝胃郁热型消化性溃疡的临床观察

Clinical observation on western and Chinese medicine for the treatment of peptic ulcer of stagnated heat in liver and stomach type by combined therapy of Chinese and western medicines

目的观察愈疡汤联合西医常规疗法治疗肝胃郁热型消化性溃疡的临床疗效。方法将104例肝胃郁热型消化性溃疡患者随机分为治疗组与对照组,每组52例。对照组予西医常规疗法,治疗组在对照组治疗措施基础上加用愈疡汤。两组疗程均为1个月,随访半年,观察胃镜疗效,比较中医证候积分、复发率、Hp再感染率的情况。结果 1治疗组、对照组胃镜总有效率分别为84.62%、63.46%;组间胃镜疗效比较,差异有统计学意义(P<0.05)。2治疗前后组内比较,两组中医证候积分差异均有统计学意义(P<0.05);组间治疗后比较,中医证候积分及其差值的差异有统计学意义,治疗组优于对照组(P<0.05)。3疗程结束后3个月、半年,治疗组复发率分别为4.76%(1/21)、23.81%(5/21),对照组复发率分别为30.77%(4/13)、53.85%(7/13);两组3个月、半年的复发率比较,差异均有统计学意义(P<0.05)。4疗程结束后3个月、半年,治疗组Hp再感染率分别为9.38%(3/32)、25.00%(8/32),对照组Hp再感染率分别为19.05%(4/21)、61.90%(13/21);两组3个月、半年的Hp再感染率比较,差异均有统计学意义(P<0.05)。结论愈疡汤联合西医常规疗法治疗肝胃郁热型消化性溃疡,可明显改善患者的临床症状,降低复发率与Hp再感染率。

Objective To observe the clinical efficacy of ＂Yushang Decoction＂ and western medicine in treating peptic ulcer of stagnated heat in liver and stomach type. Methods One hundred and four eases with peptic ulcer of stagnated heat in liver and stomach type were randomized into treatment group and control group, with 52 cases in each group. The control group was treated by western medicine and the treatment group was added with ＂Yushang Decoction＂ , with the course of one month. The clinical efficacy, TCM symptom score, recurrence rate and Hp re-infection rate were observed. Results （1）The total effective rate was 84.62% in the treatment group and 84.62% in the control group, with a difference between the two groups （ P 〈 0.05 ）. （2） There was a significant difference in TCM symptom score in both groups between before and after treatment （ P 〈 0.05 ） ; after treatment, there was a significant difference in TCM symptom score and its difference value between the two groups （ P 〈 0.05 ）. （3） The recurrence rates were 4.76% （ 1/21 ） at the 3rd month and was 23.81% （5/21） at the 6th month in the treatment group, and were 30.77% （4/13） and 53.85% （7/13） in the control group, with significant difference between the two groups （P 〈 0.05 ）. （4） After 3 months and 6 months treatment, the Hp re-infection rates were 9.38% （3/32） and 25.00% （8/32） in the treatment group, and were 19.05 % （4/21 ） and 61.90% （13/21） in the control group, with significant difference between the two groups （P 〈0.05）. Conclusion Combined ＂Yushang Decoction＂ and western medicine can improve clinical efficacy and reduce the recurrence rate and Hp re-infection rate of peptic ulcer of stagnated heat in liver and stomach type.