穴位注射骨肽注射液治疗原发性骨质疏松症临床观察

Clinical Observation of Ossotide Lnjection for Treating Primary Osteoporosis with Acupoint Injection

目的:观察穴位注射骨肽注射液治疗原发性骨质疏松症的临床疗效。方法:将40例原发性骨质疏松症患者随机分为穴位注射组(治疗组)和药物组(对照组)各20例。治疗组取腰部双侧夹脊穴(L1、L3、L5或L2、L4、S1)、足三里、血海、昆仑、太溪,穴位注射骨肽注射液;对照组予钙尔奇D片口服。治疗6个月后,观察两组患者治疗前后骨密度、T值、血生化指标碱性磷酸酶(ALP)、抗酒石酸酸性磷酸酶(TRAP)的改变。结果:治疗组患者的骨密度及T值有明显改善(P<0.05),其血ALP升高、TRAP降低,治疗前后差异有统计学意义(P<0.05);对照组治疗前后骨密度及生化指标变化无统计学差异(P>0.05)。两组比较具有显著差异(P<0.05)。结论:穴位注射骨肽注射液治疗原发性骨质疏松症的疗效较好,其作用机制可能与调节骨代谢状态有关。

Objective： To observe the clinical efficacy of ossotide injection treating primary osteoporosis with acupoint injection. Methods： 40 cases of patients with primary osteoporosis were randomly divided into the acupoint injection group and the drug group, each of 20 case. In the acupoint injection group, ossotide injection was injected with acupoint injection into the following acupoints ： jiaji of both lumbar sides （ L1, L3, L5 or L2, L4, S1 ）, zusanli, xuehai, kunlun, taixi;the drug group took oral Cahrate D tablets. 6 months after treatment, we observed the changes of BMD, T values, ALP of blood biochemistry indexes and TRAP before and after treatment in patients of two groups. Result： After treatment, BMD and T values of patients in the acupoint injection group were im- proved significantly （ P 〈 0.05 ） , ALP of blood biochemistry indexes was increased, TRAP was decreased, the difference before and after treatment had statistical significance （ P 〈 0.05 ） ; the changes of BMD and biochemical indices before and after treatment in drug group had no statistical difference （ P 〉 0.05 ）. Two groups were compared. Conclusion： The clinical efficacy of Ossotide Lnjection treating primary osteoporosis with acupoint injection is better, its mechanism of action may be related to the regulation of bone metabolism state.