1-芳基-3-芳甲酰基中氮茚的合成

Synthesis of 1-Aryl-3-aroylindolizines

合成了九个1-芳基中氮茚衍生物。首先由取代苯乙酮,碘,乙酸和吡啶四组分一锅煮反应合成中间体1-碘代中氮茚,然后在钯催化剂作用下,使用制得的的1-碘代中氮茚和芳基硼酸的Suzuki偶联反应合成得到目标化合物,所合成化合物结构通过红外,核磁及质谱进行了表征。

The paper reported the synthesis of nine 1-aryl-3-aroyl-indolizines. One-pot four-component reaction from substituted acetophenones, iodine, acetic acid and pyridine gave the intermediate 1-iodoindolizines firstly. Then a Suzuki coupling reaction of the above 1-iodoindolizines with arylboronic acids was carried out in the presence of Pd catalyst to yield the target compounds. The structures of all products was characterized by IR, HMR and MS.