咪达唑仑治疗癫痫持续状态的临床研究

Clinical Study of Midazolam in Treatment of Status Epilepticus

目的:探讨咪达唑仑治疗癫痫持续状态的临床效果。方法:选取本院2012年1月-2014年1月收治的癫痫持续状态患者52例,随机分为对照组和咪达唑林组,给予常规治疗的同时,咪达唑仑组给予咪达唑仑,对照组采用地西泮控制癫痫持续状态。结果:咪达唑仑组的总有效率为92.3%,对照组的总有效率为80.7%,两组总有效率比较差异有统计学意义(P<0.05)。咪达唑仑组癫痫状态控制时间(36.5±4.73)min,对照组的癫痫状态控制时间(47.9±5.8)min,两组的癫痫控制时间比较差异具有统计学意义(P<0.05)。咪达唑仑组合并1例肺部感染,1例低血压,对照组出现2例肺部感染,1例低血压,经过对症处理后均缓解。两组不良反应比较差异无统计学意义(P>0.05)。结论:咪达唑仑用于治疗癫痫持续状态起效快、疗效好、安全。

Objective： To investigate the efficiency of midazolam in treatment of status epilepticus. Method： 52 patients with status epilepticus （ from January 2012 to January 2014 ） were randomly divided into control group and midazolam group, the former were given conventional treatment and diazepam, while midazolam group were given conventional treatment and midazolam. Result： The tota] effective rate of midazolam group was 92.3%; the total effective rate of the control group was 80.7%, the difference was statistically significant （P〈0.05） .Midazolam group＇s control time was （ 36.5 ± 4.73 ） min, control group＇s control time was （ 47.9 ±5.8 ） min, the difference was statistically significant （P〈0.05） .There were one case of pulmonary infection, one case of hypotension in midazolam group, while two cases of pulmonary infection, one case of hypotension in control group, all these cases were relieved after symptomatic treatment.The difference was not statistically significant in adverse reactions between two groups（ P〉0.05 ）. Conclusion： Midazolam is safe, effective and rapid onset in treatment of status epileptieus.