糖尿病早期肾损害患者同型半胱氨酸和糖化血红蛋白水平分析被引量：1

导出

摘要目的探讨同型半胱氨酸(Hcy)、糖化血红蛋白(HbA1c)联合检测对糖尿病早期肾损害的价值。方法检测2013年1月至6月82例2型糖尿病(T2DM)患者的血清Hcy、HbA1c含量。其中尿微量白蛋白肌酐比(UmAlb/Cr)阳性组44例、阴性组38例。结果 U-mAlb/Cr阳性组血清Hcy、HbA1c水平明显高于阴性组(P<0.01,P<0.05);Hcy及HbA1c均与U-mAlb/Cr水平呈正相关性(P均<0.05);二者联合检测阳性率高达95.45%,明显高于单项检测水平(P<0.01,P<0.05)。结论血清Hcy、HbA1c的水平与T2DM患者的早期肾损害密切相关,联合检测对于糖尿病肾病的早期诊断、早期治疗及监测具有重要意义。

作者常友成

机构地区南京扬子医院内二科

出处《中国临床研究》 CAS 2014年第9期1092-1093,共2页 Chinese Journal of Clinical Research

关键词糖尿病肾病同型半胱氨酸糖化血红蛋白尿微量白蛋白尿肌酐

分类号 R587.2 [医药卫生—内分泌]

引文网络
相关文献

参考文献8

1常友成.2型糖尿病患者尿微量白蛋白肌酐比与血糖水平的相关性分析[J].中国临床研究,2010,23(12):1116-1116. 被引量：5
2徐红珍,王露,马正坤.同型半胱氨酸、糖化血红蛋白和尿微量白蛋白联合检测对早期糖尿病肾损伤的诊断价值[J].当代医学,2012,18(26):7-8. 被引量：28
3陈莉明.从中国糖尿病防治指南看糖尿病肾病的诊断和治疗[J].中国实用内科杂志,2009,29(6):513-516. 被引量：74
4李保村,王林辉,梅小斌.糖尿病性肾病[M].上海:上海第二军医大学出版社.2005:120-129.
5陆明,陈卫东.高同型半胱氨酸血症与糖尿病肾病相关性研究进展[J].蚌埠医学院学报,2009,34(3):272-275. 被引量：25
6Looker HC, Fagot-Campagna A, Gunter EW, et al. Homocysteine and vitamin B12 concentrations and mortality rates in type 2 diabetes [J]. Diabetes Metab Res Rev,2007,23(3) :193 -201.
7Herrmann W, Schorr H, Obeid R, et al. Disturbed homocysteine and methionine cycle intermediates S-adenosylhomocysteine and S-ade- nosylmethionine are related to degree of renal insufficiency in type 2 diabetes [ J ]. Clin Chem,2005,51 (5) :891 - 897.
8Looker HC, Fagot-Campagna A, Gunter EW, et al. Homocysteine as a risk factor for nephropathy and retinopathy in Type 2 diabetes[ J]. Diabetologia ,2003,46 (6) :766 - 772.

二级参考文献50

1Fallon UB, Virtamo J, Young I, et al. Homocysteine and Cerebral Infarction in Finnish Male Smokers [ J ]. Stroke, 2003,34 ( 6 ) :1359 -1363.
2Wald DS, Law M, Morris J. Serum homocysteine and the severity of coronary artery disease [ J ]. Thromb Res, 2003,111 ( 1 - 2 ) : 55 - 57.
3Wald DS, Law M, Morris JK. The dose-response relation between serum homocysteine and cardiovascular disease: implications for treatment and screening [ J ]. Eur J Cardiovasc Prey Rehabil, 2004,11(3) :250 -253.
4Suliman ME, Stenvinkel P, Heimbiirger O, et al. Plasma sulfur amino acids in relation to cardiovascular disease, nutritional status,and diabetes mellitus in patients with chronic renal failure at start of dialysis therapy [ J ]. Am J Kidney Dis, 2002,40 ( 3 ) : 480 - 488.
5Chambers JC, Ueland PM, Wright M, et al. Investigation of relationship between reduced, oxidized, and protein-bound homocysteine and vascular endothelial function in healthy human subjects[ J]. Circ Res,2001,89 ( 2 ) : 187 - 192.
6Pavia C, Ferrer I, Vails C, et al. Total homocysteine in patients with type 1 diabetes [ J ]. Diabetes Care, 2000,23 ( 1 ) : 84 - 87.
7Gillum R. Distribution of serum total homocysteine and its association with diabetes and cardiovascular risk factors of the insulin resistance syndrome in Mexican American men:the Third National Health and Nutrition Examination Survey [ J]. Nutr J, 2003,2(8) :6.
8Duncan GE, Li SM, Zhou XH. Age and kidney function are the primary correlates of fasting plasma total homocysteine levels in non-diabetic and diabetic adults. Results from the 1999 - 2002 National Health and Nutrition Examination Survey [ J ]. Nutr Metab (Lond) ,2005,2(5) :13.
9Sandhu JS, Singh I, Aggarwal SP, et al. Plasma homocysteine and insulin in diabetic nephropathy: relationship to body mass index [J]. Ren Fail,2004,26(6) :689 -693.
10Emoto M, Kanda H, Shoji T,et al. Impact of insulin resistance and nephropathy on homocysteine in type 2 diabetes [ J ]. Diabetes Care,2001,24 ( 3 ) :533 - 538.