摘要
三氟甲基化合物和茚酮化合物具有许多独特的理化性质和生物活性,在农药、医药、染料和功能材料领域应用广泛。以对三氟甲基苯甲醛为原料,经Knoevenagel缩合、分子内Friedel-Crafts酰化、环氧化物不对称开环等步骤,经9步反应以总收率22%得目标化合物5-三氟甲基-2-茚酮,其结构经1H NMR、13C NMR、DEPT、HR-ESI-MS和元素分析表征。
Applications of compounds containing trifluoromethyl and indanone in the fields of pesticide,medicine,dyes and function-al materials were wide,because of their unique properties of physics and chemistry as well as excellent bioactivities. Herein the 5-trifluoromethyl-2-indanone was synthesized starting from 4-trifluoromethyl benzaldehyde with the Knoevenagel condensation,Friedel-Crafts acylation and asymmetric ring opening of epoxide as the key steps through nine steps in 22%overall yields,and the product was characterized by 1 H NMR,13 C NMR,HR-ESI-MS,element analysis and found to be in good agreement with its structure.
出处
《化学研究与应用》
CAS
CSCD
北大核心
2014年第9期1445-1449,共5页
Chemical Research and Application
基金
四川省科技厅科技支撑计划项目(2009GZ0167
2012FZ0129)资助
成都师范学院项目(CS13ZB04)资助
关键词
5-三氟甲基-2-茚酮
不对称开环
缩合
合成
5-trifluoromethyl-2-indanone
asymmetric ring opening
condensation
synthesis