达菲联合中药治疗流行性感冒的临床观察

Clinical Observation of Oseltamivir Combined with Chinese Medicine for Treatment of Influenza

【目的】观察达菲联合中药治疗流行性感冒(简称流感)的疗效。【方法】将197例流感确诊病例随机分为治疗组101例和对照组96例。2组均常规给予对症、支持治疗,治疗组同时给予达菲及中药辨证治疗,对照组单纯给予达菲口服治疗。2组均用药5 d。观察2组流感症状发生率、体温降至正常时间及全部症状缓解时间,并评价2组临床疗效。【结果】(1)治疗组总有效率为98.0%,对照组为91.7%;治疗组总体疗效优于对照组,差异有统计学意义(P<0.05)。(2)治疗组能更快退热及缓解症状,与对照组比较差异有统计学意义(P<0.05或P<0.01)。(3)治疗组能够更有效缓解咽痛、肌肉酸痛、咳嗽、鼻塞流涕等流感症状,与对照组比较差异均有统计学意义(P<0.05)。【结论】达菲联合中药总体治疗效果优于单纯应用达菲,不但能够在较短时间内控制患者体温,而且能更好地改善流感症状。

Objective To observe the clinical efficacy of Oseltamivir combined with Chinese medicine for the treatment of influenza. Methods One hundred and ninety-seven cases confirmed as influenza were randomly divided into treatment group （N=101） and control group （N=96） . Both groups were given conventional symptomatic and supportive treatment. Additionally, the treatment group received Oseltamivir and Chinese medicine based on syndrome differentiation, and the control group was given Oseltamivir orally. The treatment lasted 5 days. The clinical outcomes included incidence of flu symptoms, time for body temperature decreasing to the normal and time for the relief of all symptoms in both groups. Results （1） The total effective rate of the treatment group was 98.0%, superior to 91.7% of the control group （P〈0.05） . （2） The treatment group had an effect on subsiding fever and relieving symptoms more quickly than the control group, the differences being significant （P〈 0.05 or P〈0.01） . （3） The treatment group could relieve flu symptoms of sore throat, muscular soreness, cough, nasal obstruction and discharging more effectively, and the differences were significant compared with the controlgroup （P〈0.05） . Conclusion The overall effect of Oseltamivir combined with Chinese medicine is better than Osehamivir alone, showing the advantages of subsiding fever in a relatively short period of time and relieving flu symptoms more effectively.