氨茶碱治疗新生儿胎粪吸入综合征临床研究

Clinical Research on the Neonates with Meconium Aspiration Syndrome Treated by Aminophylline

目的：观察氨茶碱治疗新生儿胎粪吸入综合征的相关临床指标变化。方法：将新生儿胎粪吸入综合征患儿26例随机分为观察组和对照组各13例。对照组采用常规治疗,观察组在常规治疗基础上加用氨茶碱。氨茶碱用生理盐水稀释成1 mg/mL,先分别在入院后1 h和3 h给予氨茶碱2.0 mg/kg静脉滴注,每次静脉滴注时间控制在20 min内,以后每12 h 1次,疗程3-5 d。观察两组相关临床指标的变化和疗效。结果：观察组患儿住院时间短于对照组[（9.23±1.54）d vs（10.50±1.27）d,P〈0.05],吸氧时间短于对照组[（2.77±1.17）d vs（3.90±0.99）d,P〈0.05],入院12 h时的呼吸频率低于对照组[（69±5）次/分vs（76±6）次/分,P〈0.01],氧合指数高于对照组（214.46±55.19 vs 170.40±0.43,P〈0.05）,总有效率高于对照组（100.0%vs 61.5%,P〈0.05）。结论：应用氨茶碱治疗新生儿胎粪吸入综合征能缩短住院及吸氧时间,改善呼吸频率和肺部氧合,且未发现明显不良反应。

Objective： To observe the effect of aminophylline on neonates with meconium aspiration syndrome（MAS）. Methods：Twenty-six neonates with MAS were randomly divided into observation group（n = 13） and control group（ n = 13）. The control group treated with conventional therapy. Based on the conventional therapy,the observation group treated with aminophylline. The clinical indicators and treatment effect between the two groups were observed. Results： The hospital stays of the observation group was shorter than that of the control group [（9. 23 ± 1. 54） d vs（10. 50 ± 1. 27） d],the difference was statistically significant（ P〈0. 05）. The oxygen dependence of the observation group was shorter than that of the control group [（2. 77 ± 1. 17） d vs（3. 90 ± 0. 99） d],the difference was statistically significant（P〈0. 05）. At hospitalized for 12 hours,the respiratory rate of the observation group lower than the control group [（69 ± 5） times ever minute vs（76 ± 6） times ever minute],the difference was statistically significant（P〈0. 01）,the oxygenation index of the observation group was higher than that of the control group（214. 46 ± 55. 19 vs 170. 40 ± 0. 43）,the difference was statistically significant（P〈0. 05）. The total effective rate of the observation group was higher than that of the control group（100. 0% vs 61. 5%）,the difference was statistically significant（P〈0. 05）. Conclusions： Aminophylline treating neonates with meconium aspiration syndrome can shorten the hospital stay and oxygen dependence,improve pulmonary oxygenation and reduce the number of breaths faster,and no adverse effects were found.