苏州地区住院儿童下呼吸道感染的病原菌分布

Pathogenic Bacteria Distribution of Hospitalized Children with Lower Respiratory Infection in Suzhou Area

目的:探讨苏州地区住院儿童下呼吸道感染性疾病的病原菌分布情况。方法:回顾性分析2007年3月至2012年12月苏州大学附属儿童医院收治的毛细支气管炎、支气管肺炎、大叶性或节段性肺炎、间质性肺炎、哮喘急性发作患儿的肺炎支原体及其他病原检测情况。结果:(1)毛细支气管炎的病原检出率依次为呼吸道合胞病毒(33.27%)、肺炎支原体(15.21%)、人类偏肺病毒(11.37%)、人类博卡病毒(4.92%)、副流感病毒-3(4.34%);(2)支气管肺炎的病原检出率依次为肺炎支原体(26.05%)、肺炎链球菌(14.72%)、呼吸道合胞病毒(8.32%)、流感嗜血杆菌(5.81%)、人类偏肺病毒(5.77%);(3)大叶性或节段性肺炎的病原检出率依次为肺炎支原体(52.25%)、肺炎链球菌(12.72%)、人类博卡病毒(5.87%)、人类偏肺病毒(4.70%)、呼吸道合胞病毒(2.94%);(4)间质性肺炎的病原检出率依次为肺炎支原体(39.15%)、呼吸道合胞病毒(23.64%)、腺病毒(6.98%)、人类博卡病毒(3.49%)、肺炎链球菌(3.49%);(5)哮喘急性发作病原检出率依次是肺炎支原体(30.81%)、肺炎链球菌(15.01%)、呼吸道合胞病毒(13.15%)、人类偏肺病毒(10.09%)、流感嗜血杆菌(5.71%)、人类博卡病毒(3.05%)。结论:肺炎支原体感染是儿童下呼吸道感染的重要病原,分别是引起大叶性或节段性肺炎、间质性肺炎、支气管肺炎最常见的单一病原,也是引起毛细支气管炎、哮喘急性发作仅次于病毒的第二常见病原。

Objective： To observe the pathogenic bacteria distribution of hospitalized children with lower respiratory infection in Suzhou area. Methods： Mycoplasma pneumoniae and other pathogen of hospitalized children with bronchiolitis,bronchopneumonia,lobar or segmental pneumonia,interstitial pneumonia,asthma attack from March 2007 to December 2012 were retrospectively analyzed. Results：（1） Bronchiolitis pathogen was Respiratory syncytial virus（RSV）（33.27%）,followed by Mycoplasma pneumonia（MP）（15.21%）,Human metapneumovirus（ hMPV）（ 11. 37%）,Human boka virus（ HBoV）（ 4. 92%）,Parainfluenza virus-3（ 4. 34%）.（ 2）Bronchopneumonia pathogen was MP（ 26. 05%）,followed by Streptococcus pneumonia（ Sp）（ 14. 72%）,RSV（ 8. 32%）,Haemophilus influenza（ Hi）（5. 81%）,hMPV（5. 77%）.（3） Lobar or segmental pneumonia pathogen was MP（52. 25%）,Sp（12.72%）,HboV（5.87%）,hMPV（4.70%）,RSV（2.94%）.（4） Interstitial pneumonia pathogen was MP（39.15%）,followed by RSV（ 23. 64%）,Adenovirus（ Adv）（ 6. 98%）,HboV（ 3. 49%）,Sp（ 3. 49%）.（ 5） Asthma attack pathogen was MP（30.81%）,followed by Sp（15.01%）,RSV（13.15%）,hMPV（10.09%）,Hi（5.71%）,HboV（3.05%）. Conclusions： MP was the important cause of lower respiratory tract diseases in children,which was most common in lobar or segmental pneumonia,interstitial pneumonia,bronchopneumonia respectively,second cause in bronchiolitis and asthma attack foIIowed by virus.