右旋糖酐40葡萄糖注射液致儿童不良反应7例分析

Adverse Drug Reactions of Dextran 40 Glucose Injection to Children: an Analysis of 7 Cases

目的:通过对右旋糖酐40葡萄糖注射液引起儿童药品不良反应(ADR)病例的分析,总结临床应用该药时的注意事项,为右旋糖酐40葡萄糖注射液的合理应用提供参考。方法:收集2013年我院应用右旋糖酐40葡萄糖注射液发生药品不良反应的患儿病例7例,应用Excel软件从用法用量、发生不良反应时间等方面进行总结和分析。结果:右旋糖酐40葡萄糖注射液的药品不良反应多发生在给药过程中或给药结束2 h内,严重药品不良反应更容易发生在第1次给药时。结论:临床上给予患儿右旋糖酐40葡萄糖注射液治疗,在第1次给药时应密切观察患儿症状、体征,并做好充分的不良反应防治措施准备,以防严重药品不良反应的发生;过敏体质者,建议做皮试后再用。

Objective： Intent to avoid the adverse reactions of dextran 40 glucose injection,to improve the reasonable treatment of dextran 40 glucose injection on children. Methods： Seven cases of pediatrics who suffered adverse reactions from dextran 40 glucose injection in 2013 were collected. Usage,dosage,and the time of adverse reactions occurrence were analyzed. Results： The adverse reactions of dextran 40 glucose injection mostly appear in the process of administration or under 2 hours after the administration. The serious adverse reactions mostly occur in the beginning of the first administration. Conclusions： We should have a close observation when we give the intravenous drip of dextran 40 glucose injection,especially to those who never administrated dextran 40 glucose injection before. At the same time,intent to prevent the occurrence of serious adverse reactions,we should make adequate preparation.If the children are allergies,skin test is needed before the administration.