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Claudins蛋白及其在急性肾损伤中的研究进展

Research Progress on Claudins and the Role in Acute Kidney Injury
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摘要 紧密连接蛋白由多种跨膜蛋白共同构成,包括claudin、occludin和连接粘附分子(JAMs),以及相应的适应蛋白和粘连蛋白如ZO-1、ZO-2、ZO-3、菌环蛋白等外周胞浆蛋白组成。紧密连接不仅能调控离子从细胞一侧扩散到另一侧,还能阻止细胞膜顶端和基底侧面成分的相互混合,对保持细胞的极性有重要作用,而且参与细胞增殖、分化的调节。
作者 张良 李志辉
机构地区 湖南省儿童医院
出处 《儿科药学杂志》 CAS 2014年第9期56-60,共5页 Journal of Pediatric Pharmacy
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