过敏性鼻炎与支气管哮喘患者的Fe NO比较研究

Analysis of fractional exhaled nitric oxide for allergic rhinitis and bronchial asthma

目的探讨呼出气一氧化氮(Fe NO)在支气管哮喘(BA)和过敏性鼻炎(AR)患者中的应用,比较Fe NO和外周血嗜酸粒细胞分类(EOS%)在健康对照组(A组)、AR(B组)、BA/AR(C组)及BA(D组)之间的不同,寻找两种疾病Fe NO、EOS%改变的意义,以及两种疾病之间的关系。方法采用按国际技术标准设计的尚沃纳库仑一氧化氮分析仪对A、B、C、D组患者检测Fe NO,同时测定各组患者血常规。结果三组病例ROC曲线下面积均大于0.5;AR、BA/AR、BA三组Fe NO、EOS%水平均高于对照组(P<0.05),三组组间无明显差异(P>0.05);Fe NO与EOS%间存在显著相关性(r=0.505,P<0.0 5)。结论Fe NO诊断支气管哮喘和过敏性鼻炎有临床意义。Fe NO可以反映患者气道嗜酸性炎症水平。过敏性鼻炎与支气管哮喘这两种疾病存在密切的关系。

Objective To discuss the application of exhaled nitric oxide（ FeNO） on patients with bronchial asthma（ BA） and allergic rhinitis（ AR）,and to investigate the significance and relationship in FeNO and EOS%between allergic rhinitis and bronchial asthma. Methods FeNO was measured by Sunvou nitric oxide analyzer according to the international standard design. FeNO test and blood routine examination were performed in all of the enrolled patients. Results The area under ROC curve was greater than 0. 5. Compare to the normal control group,FeNO concentration in patients with AR,BA /AR and BA showed higher than those in the control group with significant difference（ P〈0. 05）. There was significant correlation between FeNO concentration and EOS% in patients（ r =0. 505,P〈0. 05）. There was no significant difference in FeNO concentration among the patients who were suffering from BA,BA /AR,AR（ P〉0. 05）. Conclusion FeNO have clinical significance in the diagnosis of bronchial asthma and allergic rhinitis. There is a close relationship between allergic rhinitis and bronchial asthma.