COPD并发肺动脉高压与Rho激酶表达的相关性分析

Correlation analysis of ROCK1 expression in elderly COPD patients complicated with pulmonary arterial hypertension

目的分析老年COPD患者并发肺动脉高压与血清Rho激酶表达的相关性。方法分析我院接受治疗的COPD患者的临床资料。依据患者是否合并肺动脉高压分为观察组、对照组。结果共纳入观察组38例,对照组40例。观察组患者肺动脉平均压、血清ROCK1、单核细胞ROCK1、肿瘤坏死因子α及C-反应蛋白水平均显著高于对照组(P<0.001)。观察组患者血清ROCk1水平与肺动脉高压呈现显著性正相关(P<0.001)。观察组患者单核细胞ROCk1水平与肺动脉高压呈现显著性正相关(P=0.004)。结论合并肺动脉高压的老年COPD患者,外周血及单核细胞内ROCK1表达均升高,且与肺动脉平均压力呈现正相关。提示ROCK1是干预COPD向肺动脉高压进展的新靶点。

Objective To explore the correlation of ROCK1 in elderly COPD patients complicated with pulmonary arterial hypertension. Methods The clinical data of COPD patients from Jan 2012 to Jun 2013 were collected. 38 COPD patients complicated with pulmonary arterial hypertension were selected as the observation group,and40 COPD patients without pulmonary arterial hypertension were taken as the control group. Results The mean values of mean pulmonary arterial pressure,ROCK1 in blood and monocytes,TNF-αand CRP in the observation group were significant higher than those in the control group（ P〈0. 001）. In the observation group,there was a positive correlation between the blood ROCK1 and the pulmonary arterial pressure（ r = 0. 624,P〈0. 001） and a positive correlation between the monocytes ROCK1 and the pulmonary arterial pressure（ r = 0. 459,P = 0. 004）. Conclusion The expression of ROCK1 in blood and monocytes increases in COPD patients with pulmonary arterial hypertension,and there is a positive correlation between ROCK1 and pulmonary arterial pressure. ROCK1 may be a new target to prevent COPD developing into pulmonary arterial hypertension.