血浆N末端B型利钠肽原水平对急诊呼吸困难病人的应用价值

Application value of plasma NT-proBNP levels in the differentiation of emergency patients with dyspnea

目的分析并评价血浆N末端B型利钠肽原(NT-proBNP)含量对急诊呼吸困难病人鉴别的应用价值。方法将我院急诊科自2012年3月至2013年11月期间收治的194例受检者分为心源性呼吸困难组110例与肺源性呼吸困难组84例。对两组患者的血浆NT-proBNP水平进行检测并检查心脏超声,对比分析两组患者的血浆NT-proBNP水平与左室射血分数;对心源性呼吸困难患者的血浆NT-proBNP水平与左室射血分数之间的相关性进行分析。结果心源性呼吸困难组患者的血浆NT-proBNP含量显著高于肺源性呼吸困难组患者(t=21.093,P=0.001),具有统计学意义;心源性呼吸困难组患者的LVEF水平显著低于肺源性呼吸困难组(t=18.093,P=0.001),具有统计学意义。心源性呼吸困难组患者的血浆NT-proBNP水平与LVEF之间呈负相关关系(r=-0.59,P<0.01)。结论血浆NT-proBNP水平在急性呼吸困难患者的诊断方面具有重要的应用价值。

Objective To analyze and evaluate the levels of plasma NT-proBNP in the differentiation of emergency patients with dyspnea. Methods 194 patients were divided into the cardiac dyspnea group（ 110 cases）and the pulmonary dyspnea group（ 84 cases）. The level of plasma NT-proBNP was detected and they were also given heart ultrasound. The relationship between plasma NT-proBNP level and left ventricular ejection fraction was analyzed. Results The level of plasma NT-proBNP was obviously higher in the cardiac dyspnea group than in the pulmonary dyspnea group（ t = 21. 093,P = 0. 001）. The level of LVEF was obviously lower in the cardiac dyspnea group than in the pulmonary dyspnea group（ t = 18. 093,P = 0. 001）. There was a negative correlation between the level of plasma NT-proBNP and LVEF in patients with cardiogenic dyspnea（ r =- 0. 59,P〈0. 01）. Conclusion The level of plasma NT-proBNP has important application value in the diagnosis of patients with acute dyspnea.