莫西沙星联合卷曲霉素治疗耐多药肺结核的临床效果观察

Clinical effect of moxifloxacin combined with capreomycin in the treatment of multi-drug resistant tuberculosis

目的对莫西沙星联合卷曲霉素治疗耐多药肺结核的临床效果进行探讨。方法选取108名在我院进行治疗的耐多药肺结核的患者,随机分成对照组和实验组,平均每组54人。对照组通过使用莫西沙星治疗耐多药肺结核,实验组则采用莫西沙星联合卷曲霉素治疗耐多药肺结核。比较并观察两组患者治疗后的临床效果。结果两组患者经过一段时间的治疗后,实验组的病灶总吸收率(88.33%)、空洞闭合有效率(85.19%)明显高于对照组的病灶总吸收率(57.40%)、空洞闭合有效率(59.62%),统计学上有意义(P<0.05)。结论通过观察分析使用莫西沙星联合卷曲霉素治疗耐多药肺结核的疗效明显好于单独使用莫西沙星的治疗效果,病灶吸收和空洞闭合明显高于对照组。治愈率高,无不良反应,安全可靠,值得在临床上广泛应用。

Objective To explore the clinical effect of moxifloxacin combined with capreomycin in the treatment of multi-drug resistant tuberculosis. Methods 108 patients with multi-drug resistant tuberculosis were randomly divided into two groups,54 cases in each group. The control group was treated with moxifloxacin,and the experiment group was treated with moxifloxacin combined with capreomycin. The clinical effect of the two groups was observed after the treatment. Results The total absorption rate of lesion was 88. 33% and the cavity closure rate was85. 19% in the experiment group,which were significantly higher than those in the control group（ 57. 40% and59. 62%）（ P〈0. 05）. Conclusion The application of moxifloxacin combined with capreomycin is more effective than moxifloxacin alone in the treatment of patients with multi-drug resistant tuberculosis,which has higher cure rate and no obvious adverse reactions.