三七总皂苷对癌性贫血患者促红细胞生成素的调节作用

The regulation effect of panax notoginseng saponins on erythropoietin in patients with anemia of cancer

目的利用三七总皂苷治疗癌性贫血患者,观察患者治疗后体内促红细胞生成素（EPO）的变化,判断三七总皂苷对癌性贫血患者EPO的调节作用。方法将浙江中医药大学附属温州市中医院2012年2月~2014年1月收治的癌性贫血患者随机分成正常对照组、三七总皂苷治疗组、力蜚能治疗组、益比奥治疗组。运用酶联免疫法及临床常规检查,测定各组患者每周内EPO浓度变化,并用统计学方法加以分析。结果三七总皂苷治疗组对EPO有正向调节作用,与正常对照组、力蜚能治疗组比较,差异有统计学意义（P〈0.05）;但与益比奥治疗组比较,差异无统计学意义（P〉0.05）。结论三七总皂苷可使癌性贫血患者体内EPO升高,对癌性贫血患者EPO有正向调节作用,可应用于临床癌性贫血患者的治疗。

Objective To observe the changes in erythropoietin （EPO） after using panax notoginseng saponins （PNS） in treatment of patients with anemia of cancer, and then to judge the regulating effect of PNS to EPO. Methods The patients with anemia of cancer admitted to Wenzhou Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University from February 2012 to January 2014 were randomly divided into normal control group, PNS treatment group, Lifeineng treatment group, Yibiao treatment group. The concentration changes of EPO within each week of every group were determined by using enzyme-linked immunosorbent assay and clinical routine examination, and the dates was analyzed by statistical methods. Results PNS treatment group had a positive effect on the regulation of EPO. With the normal control group and Lifeineng treatment group compared, there was a statistical significance （P 〈0.05）. But compared to Yibiao treatment group, there was no significant difference （P 〈0.05）. Conclusion The experimental results show that PNS can increase the EPO in patients with anemia of cancer, and has a positive moderating effect on the EPO, it can treat the patients with clinical anemia of cancer.