APRIL和XIAP在结肠癌、结肠腺瘤及正常结肠黏膜中的表达及意义

Expression and clinical significance of APRIL and XIAP in colon carcinoma,colon adenoma and normal colon mucosa

目的探讨增殖诱导配体(APRIL)和X连锁凋亡抑制蛋白(XIAP)在结肠癌、结肠腺瘤及正常结肠黏膜组织中的表达及其临床意义。方法应用免疫组织化学EnVision法检测结肠癌组织标本60例、结肠腺瘤30例及正常结肠黏膜组织30例中APRIL和XIAP的表达。结果结肠癌、结肠腺瘤及正常结肠黏膜组织中APRIL和XIAP的阳性表达率均呈逐渐降低趋势,3组间APRIL和XIAP的阳性表达率比较,差异有统计学意义(P<0.01)。结肠癌组织中APRIL的阳性表达与组织分级、淋巴结转移以及浸润程度密切相关(P<0.01);XIAP的阳性表达与Dukes分期、淋巴结转移以及浸润程度密切相关(P<0.01)。结论 APRIL和XIAP的表达增高不仅可能在正常黏膜-腺瘤-癌的病理形成过程中起一定作用,更与结肠癌浸润、转移等恶性生物学行为有密切关系。

Objective To investigate the expression and clinical significance of a proliferation-inducing ligand （APRIL） and X-linked inhibitor of apoptosis protein （XIAP） in colon carcinoma,colon adenoma and normal colon mucosa. Methods The expression of APRIL and XIAP was detected by immunohistochemical EnVisionTM plus non-hiotin tech-nique in 60 cases of colon carcinoma and 30 cases of colon adenoma,30 cases of normal colon mucosa. Results The positive expression rates of APRIL and XIAP in colon carcinoma,colon adenoma and normal colorectal mucosa de-creased gradually.There was significant difference among the three groups （P〈0.01）.The expression of XIAP were close-ly related to Dukes clinical stage,lymph node metascasis and the degree of infiltration （P〈0.01）.The expression of APRIL were closely related to differentiation degree,lymph node metascasis and the degree of infiltration （P〈0.01）. Conclusion The high expression of APRIL and XIAP may play important roles in the carcinogenesis of colon carcino-ma and it is involved in the metastasis and infiltration.