序贯疗法治疗慢性荨麻疹的临床观察

Clinical observation on sequential therapy for treatment of chronic urticaria

目的：观察序贯疗法治疗慢性荨麻疹的临床效果。方法选择2013年1月~2014年3月本院收治的64例慢性荨麻疹患者为研究对象，将其随机分为观察组和对照组，每组各32例。观察组先采用依斯巴汀注射液治疗，待症状减轻后，再服用依斯巴汀片治疗；对照组采用赛庚啶治疗，观察对比两组患者的临床疗效和临床指标。结果观察组的临床总有效率为75.0%，对照组为50.0%，两组差异有统计学意义（P〈0.05）。观察组与对照组比较，其治疗后的瘙痒、风团数目，风团大小，持续时间差异均有统计学意义（P〈0.05）。结论依斯巴汀序贯疗法治疗慢性荨麻疹的临床效果显著，值得临床推广应用。

Objective To observe the clinical effect of sequential therapy for treatment of chronic urticaria. Methods 64 patients with chronic urticarial treated in our hospital from Jan 2013 to Mar 2014 were selected as research objects and randomly divided into the observation group and the control group,with 32 cases in each group.The observation group was given ebastine injection first then ebastine tablet after symptom remission.The control group was given cyproheptadine.The clinical efficacy and clinical index were observed and compared between the two groups. Results The clinical total effective rate was 75.0% in the observation group and 50.0% in the control group,with statistical dif-ference （P〈0.05）.The observation group and the control group had statistical difference regarding pruritus,wheal number, wheal size and duration after treatment （P〈0.05）. Conclusion Sequential therapy with ebastine has significant clinical effect for treatment of chronic urticarial,which is worthy of clinical promotion and application.