黄芪对儿童过敏性鼻炎哮喘综合征的免疫调节及临床疗效观察

Observation on immunoregulating effect： of Baaikal Skullcap Root on children with combined allergic rhinitis and asthma syndrome and the therapeutic effect

目的：观察黄芪对儿童过敏性鼻炎哮喘综合征免疫调节作用及临床治疗效果。方法：将60例过敏性鼻炎哮喘综合征患儿随机分为治疗组和对照组各30例，对照组患儿进行常规治疗，治疗组在常规治疗的基础上给予黄芪治疗：两组均随访6个月，第1、3、6个月各随访1次，并检测两组患儿治疗前、后临床症状的评分及治疗前、后血清总IgE及嗜酸性粒细胞（EOS）计数水平，CD3、CD4、CD8及CD4／CD8水平。结果：黄芪治疗后临床症状的评分明显降低，CD3、CD4及CD4／CD8水平均明显升高，血清总IgE及EOS明显降低，治疗组治疗后与对照组治疗后比较差异有统计学意义（P〈0．05）。结论：黄芪可调节过敏性鼻炎哮喘综合征的纪疫功能，具有临床实用价值。

Objective： To observe the immmunoregulalting effect of Baikal Skullcap Root on childres with combined allergic rhinitis and asthma syndrnme （CARAS） and the therapeutic effect. Methods： Sixty CARAS children were randomly divided into treatment group and control group, 30 children in each group. The children in control group were treated with conventional therapy,while the children in treatment group were treated with Baikal Skullcap Root based on conventional treatment.The children in the two groups were followed up for six months, follow -up was performed on the first month, the thid month and the sixth month,respectively;the scores of clinical symptoms, the serum total IgE levels and eosinophil （EOS） eounls. CD3 , CD4. CD8 levels and the ratios of CD4/CD8 inthe two groups before and after treatment were detected. Results： After treatment, the score of clinical symptoms in treatment group decreased significantly, CD3, CD4 levels and the ratio of CD4/CD8 increased significantly, serum total IgE level and EOS count decreased significantly . compared with control group after treatment, there were statislically significant differences （P 〈0.05 ） .Conclusion：Baikal Skullcap Root can regulate the immune function of children with CARAS. which has clinical practical value.