抗癌药物吡咯[2,3-d]嘧啶化合物的合成研究

Study on the Synthesis of Anticancer Drug Pyrrolo [2,3-d] Pyrimidines

文章主要研究了L-脯氨酸催化下抗癌药物吡咯[2,3-d]嘧啶化合物的合成。以硝基烯和2,4-二氨基-6-羟基嘧啶为底物,考察了在不同实验条件下,不同催化剂,对反应收率的影响。结果表明,以乙醇为溶剂,L-脯氨酸为催化剂,室温反应时,产物的收率最高,可达85%。该实验方法具有反应条件温和、操作简单、产率较高等优点。并通过核磁共振等对化合物的结构进行表征。

In the thesis, we mainly studied the synthesis of anticancer drug pyrrolo [2,3-d] pyrimidine. We study the effect of yield of the reaction under different experimental conditions with nitrootefin and 2-amino-4,6-dihydroxypyrimidine as substrates. The results show that the excellent yield （85 %） can be obtained with L-proline as catalyst in ethanol at r.t. The method has the advantages of mild reaction conditions, simple operation, high yield. The structural assignment has been confirmed by NMR analysis.