45例Panayiotopoulos综合征的临床特征及脑电图分析

Clinical analysis and electroencephalography features in idiopathic childhood occipital epilepsy of Panayiotopoulos

目的探讨45例Panayiotopoulos综合征的脑电图及临床特征、预后情况。方法收集我院小儿神经科2010年6月~2013年6月Panayiotopoulos综合征45例临床资料,并进行分析。结果其中33例以发作性呕吐为主要症状就诊。20例患儿癫痫发作持续半小时以上,28例发作开始于睡眠期。28例患儿发作间期脑电图为枕区或后头部棘波、棘慢波发放。32例患儿一种药物可有效控制发作。结论 Panayiotopoulos综合征临床表现以自主神经发作及自主神经持续状态多见,发作间期脑电图大部分为后头部功能性尖波、尖慢波发放,抗癫痫药控制良好,预后好。

Objective To investigate the clinical electroeneephalography features and prognosis in children with idiopathic occipital epilepsy of Panayiotoponlos. Methods A retrospective review of 45 children patients who are diagnosed as idiopathic occipital epilepsy of Panayiotopoulos from June 2010 to June 2013 was conducted. Results 33 patients starts with ictal emetic. Nearly half of these seizures last more than 30 min, 62.2% of seizures start in sleep. Interictal EEG （62.2%） showed high-amplitude sharp,spike and wave discharge on the unilateral or bilateral occipital and posterior regions. Most of them were treated monotherapy. Conclusion Panayiotopoulos syndrome is mainly autonomic seizures and autonomic status epilepticus. Most of EEG reveals functional, mainly multi-focal, sharp, sharp-slow wave complexes. Spikes often occurs at posterior locations. The outcome of treatment with antiepileptic drugs is always good,and the prognosis is mostly favorable.