期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

内质网应激在帕金森病中的作用 被引量：5

下载PDF
导出
摘要 帕金森病（PD）是仅次于阿尔茨海默病（AD）的年龄相关性神经变性病,主要的临床症状为运动迟缓、肌肉僵直、静止性震颤和姿势不稳;其神经变性特征为进行性黑质致密部（SNc）多巴胺能（DA）神经元变性、缺失、以及神经元内出现由α-共核蛋白（α-synuclein）组成的Lewy小体的形成。
作者 吴亮 张颖冬
机构地区 南京医科大学附属南京医院神经内科
出处 《中风与神经疾病杂志》 CAS CSCD 北大核心 2014年第8期760-762,共3页 Journal of Apoplexy and Nervous Diseases
基金 国家自然科学基金(81271418)
关键词 帕金森病 神经变性 多巴胺能 黑质致密部 静止性震颤 运动迟缓 阿尔茨海默病 年龄相关性 神经元变性 肌肉僵直
分类号 R742.5 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献23

  • 1Naidoo N. ER and aging-Protein folding and the ER stress response [ J]. Ageing Res Rev,2009,8(5) :150 - 159.
  • 2Ron D,Walter P. Signal integration in the endoplasmic reticulum unfolded protein response[J]. Nat Rev Mol Cell Biol,2007,8(7) :519 -529.
  • 3Mccullough KD, Martindale JL, Klotz LO, et al. Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bct2 and perturbing the cellular redox state[ J]. Mol Cell Biol,2001,21 (4) : 1249 - 1259.
  • 4Fu HY,Okada K, Liao Y, et al. Ablation of C/EBP homologous pro-tein attenuates endoptasmic reticulum-mediated apoptosis and cardiac dysfunction induced by pressure overload [ J ]. Circulation, 2010,122 (4) :361 -369.
  • 5Li G,Mongillo M,Chin KT,et al. Role of EROl-alpha-mediated stimula- tion of inositol 1,4,5-triphosphate receptor activity in endoplasm/c reticu- lum stress-lnduced apoptosis[ J]. J Cell Bol,2039,186(6) :783 -792.
  • 6Halterman MW, Gill M, Dejesus C, et al. The endoplasmic reticulum stress response factor CHOP-IO protects against hypoxia-induccd neu- ronal death [ J ]. J Biol Chem,2010,285 (28) :21329 - 21340.
  • 7Klee M, Pallauf K, Alcala S, et al. Mitochondrial apoptosis induced by BH3-only molecules in the exclusive presence of endoplasmic reticular Bak[ J]. EMBO J,2009,28 (12) : 1757 - 1768.
  • 8Oda T, Kosuge Y, Arakawa M, et al. Distinct mechanism of cell death is responsible for tunicamycin-induced ER stress in SK-N-SH and SH- SY5Y cells[J]. Neurosci Res,2008,60( 1):29 -39.
  • 9Hoozemans JJ, van Haastert ES, Eikelenboom P, et al. Activation of the unfolded protein response in Parkinson' s disease [ J ]. Biochem Biophys Res Comnaun ,2007,354( 3 ) :707 - 711.
  • 10Jiang P,Gan M,Ebrahim AS,et al. ER stress response plays an im- portant role in aggregation of alpha-synuclein [ J ]. Mol Neurodegen- er,2010,5:56.

同被引文献39

  • 1张晓录 ,张逢春 ,李尧华 .酪氨酸羟化酶与帕金森病的关系研究[J].北华大学学报（自然科学版）,2005,6(3):224-227. 被引量：12
  • 2赵喜林,顾振纶,秦正红.长期低剂量皮下注射鱼藤酮制作大鼠帕金森病模型[J].中国药理学通报,2005,21(10):1274-1277. 被引量：27
  • 3Wirdefeldt K, Adam HO, Cole P, et al. Epidemiology and etiolo- gy of Parkinson's disease., a review of the evidence [J]. Eur J Epidemiol, 2011,26 ( Suppl 1 ) : 1-58.
  • 4Cuervo AM,Stefanis L,Fredenburg R, et al. Impaired degrada tion of mutant alpha-synuclein by chaperone-mediated autoph- agy[J]. Science,2004,305(5 688):1 292-1 295.
  • 5Kuma A, Mizushima N. Physiological role of autophagy as an intracellular recycling system[J]. Semin Cell Dev Biol, 2010,21 (7) :683-690.
  • 6Vogiatzi T, Xilouri M, Vekrellis K, et al. Wild type a-synuclein is degraded by chaperone mediated autophagy and macroauto phagy in neuronal cells [J]. Biol Chem,2008,283(35):42-56.
  • 7Lutz AK,Exner N,Fett ME,et al. Loss of parkin or PINK1 function increases Drpl-dependent mitochondrial fragmenta- tion[J]. Journal of Biological Chemistry, 2009,284 (34) : 22 938-22 951.
  • 8Sandebring A, Thomas KJ, Beilina A, et al. Mitochondrial al terations in PINK1 deficient cells are influenced by calci- neurin-dependent dephosphorylation of dynaminrelated protein 11-17. PLOS ONE,2009,4(5) :5 701.
  • 9Geisler S, Holmstrom KM, Skujat D, et al. PINK1/Parkin-mei- dated mitophagy is dependent on VDAC1 and p62/SQSTMI [J]. Nat Cell Biol,2010,12(2) :119-131.
  • 10Deng H, Dodson MW, Huang H, et al. The Parkinsons's dis- ease genes pinkl and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila[J]. Proc Natl Aead Sei USA,2008,105(38):14 503-14 508.

引证文献5

二级引证文献26

中风与神经疾病杂志
2014年 第8期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部