阳离子扩散促进子(CDF)家族蛋白的研究进展

Research progress on cation diffusion facilitator(CDF) family proteins

阳离子扩散促进子家族(Cation diffusion facilitator family,CDF)是一类负责转运重金属离子的新型蛋白质家族。该家族蛋白主要定位在包括细菌的细胞膜、植物和酵母的液泡膜以及哺乳动物的高尔基体在内的各类膜或膜系统上。CDF家族蛋白由于在维持生物体内金属离子的体内平衡、解除金属过度积累对生物造成的毒性以及生物修复等方面的重要作用而受到了人们的广泛关注,其结构特征、拓扑学分析、保守的特征序列、底物专一性、转运机制以及系统发育学等已被深入研究。本文从以上几个方面对CDF家族蛋白的有关研究进展进行了综述,并对其未来的研究方向予以展望。

Cation diffusion facilitator（ CDF） proteins are a novel phylogenetically ubiquitous family of the intermembrane transporters which are believed to play a role in the transportation of a wide range of heavy metal ions across membranes. The CDF proteins were found in a host of membranes,including bacterial cell membranes,the vacuolar membranes of both plants and yeast and the golgi apparatus of animals. Due to their significant roles in the maintenance of the homeostasis of heavy metal cations,the removal of excessive accumulation of toxic heavy metals and bioremediation,CDF proteins have been intensively investigated in recent years. Research progress on CDF proteins focuses mainly on their structural characteristics,topological analysis,conservative signature sequence,substrate specificity,transporting mechanism and phylogenetic analysis. In this paper,the above aspects of the CDF proteins are outlined,and future research is prospected.