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聚晶制粒技术的研究进展 被引量：2

Advance on Crystallo-co-Agglomeration Based Particle Engineering Technique
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摘要 目的介绍聚晶制粒技术制备药物微粒的研究进展。方法以近年来的研究文献为基础,对聚晶制粒技术的原理、制备过程、影响因素、质量评价、最新进展和发展趋势等方面进行归纳总结。结果与结论与球晶技术相比,聚晶制粒技术在制备药物微粒上有自身的特色,具有发展潜力和应用前景。 OBJECTIVE To introduce the erystallo-co-agglomeration （CCA） approach and its recent pharmaceutical progress. METHODS The forming mechanism, the manufacturing process, the evaluation parameter and the current trends of the CCA-based particle engineering technique have been summarized based on the literature at home and abroad. RESULTS AND CONCLUSION Compared to the spherical crystallization, the CCA have definite advantages thus develop rapidly in recent years.
作者 申瑞芳 单利 高春生
机构地区 军事医学科学院毒物药物研究所 河南大学药学院
出处 《中国药学杂志》 CAS CSCD 北大核心 2014年第17期1481-1485,共5页 Chinese Pharmaceutical Journal
基金 国家科技重大专项--综合性新药研究开发技术大平台资助项目(2012ZX09301003-001)
关键词 聚晶制粒 球晶 直接压片 多元微粒药物传输系统 crystallo-co-agglomeration spherical crystallization direct compression multiple units particulate drug deliverysystem
分类号 R944 [医药卫生—药剂学]
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参考文献31

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二级参考文献25

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共引文献15

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中国药学杂志
2014年 第17期

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