雪里见的化学成分研究

Chemical Constituents of Arisaema rhizomatum

目的研究雪里见球茎的化学成分。方法运用多种色谱技术分离雪里见球茎中化学成分,采用波谱技术和理化性质确定化合物的结构。结果分离得到12个化合物,分别鉴定为β-谷甾醇(1),β-胡萝卜苷(2),芹菜素-7-O-β-D-葡萄糖醛酸苷(3),新橄榄脂素(4),oldhamactam(5),O-ethyllycorenine(6),α-细辛醚(7),(R)-bgugaine(8),5,7,4'-三羟基-3'-甲氧基黄酮(9),芹菜素-6-C-半乳糖-8-C-阿拉伯糖苷(10),异夏佛托苷(11)和尿苷(12)。结论化合物5、6为首次从该属植物中得到,化合物3、4、7、10、11和12为首次从该植物中分离得到。

OBJECTIVE To investigate the chemical constituents of Arisaema rhizomatum. METHODS The constituents were isolated and purified by silica gel and Sephadex LH -20 column chromatography and preparative TLC. Their structures were identified on the basis of spectral data and physiochemical characteristics. RESULTS Twelve compounds were isolated from 70% ethanol ex- tracts and identified as β-sitosterol （ 1 ）, daucosterin （ 2 ） , apigenin-7- O-β-D-glucuronide （ 3 ） , neo-olivil （ 4 ） , oldhamactam （ 5 ） , O-ethylly- corenine （ 6 ）, α-asarone （ 7 ）, （ R ） -bgugaine （ 8 ）, 5,7,4＇-trihydroxy-3＇-methoxyflavone （ 9 ）, apigenin-6-C-galactosyl-8-C-arabinoside （10）, isoschaftoside（ 11 ） and uridine（12）. CONCLUSION Compounds 5 and 6 are reported from the plants in genus Arisaema. for the first time. Compounds 3,4,7,10,11 and 12 are isolated from this plant material for the first time.